CMOS-based implantable glucose monitoring device with improved performance and reduced invasiveness
CMOS-based implantable glucose monitoring device with improved performance and reduced invasiveness
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基于 CMOS 的植入式血糖监测设备，具有改进的性能和减少的侵入性
DOI：
10.1049/el.2015.0612
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发表时间：
2015
影响因子：
1.1
通讯作者：
S. Takeuchi and J. Ohta
中科院分区：
文献类型：
--
作者：
T. Kawamura;K. Masuda;T. Hirai;Y. Ohta;M. Motoyama;H. Takehara;T. Noda;K. Sasagawa;T. Tokuda;T. Okitsu;S. Takeuchi and J. Ohta
开发了一种基于CMOS线传感器结合葡萄糖响应荧光水凝胶的植入式葡萄糖监测装置。实现了具有足够灵敏度和响应时间的植入式葡萄糖监测器械，这是对作者先前概念验证器械的改进。传感器尺寸的减小使得器械直径可使用市售16号注射器针头注射。该传感器的性能通过体外和体内实验得到了证实。
An implantable glucose monitoring device based on a CMOS line sensor combined with a glucose‐responsive fluorescent hydrogel is developed. An implantable glucose monitoring device with sufficient sensitivity and response time is realised, which is an improvement over the authors' previous proof‐of‐concept device. A reduction of the sensor size made the device diameter injectable with a commercially available 16‐gauge syringe needle. The sensor's performance was confirmed through bothin vitroandin vivoexperiments.