Use of Newborn Screening Program blood spots for exposure assessment: Declining levels of perfluorinated compounds in New York State infants
Use of Newborn Screening Program blood spots for exposure assessment: Declining levels of perfluorinated compounds in New York State infants
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DOI：
10.1021/es8006244
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发表时间：
2008-07-15
影响因子：
11.4
通讯作者：
Eadon, George A.
中科院分区：
文献类型：
--
作者：
Spliethoff, Henry M.;Tao, Lin;Eadon, George A.
时间生物监测研究可以评估人口接触污染物的变化，但收集具有充分代表性和足够时间分辨率的生物标本可能需要大量资源。新生儿筛查计划（NSP）从几乎所有在美国出生的婴儿中收集滤纸上干燥斑点的血液。在这项研究中，我们调查了使用NSP血斑的时间生物监测分析全氟辛烷磺酸盐（PFOS），全氟辛烷磺酰胺（PFOSA），全氟己烷磺酸盐（PFHxS），全氟辛酸（PFOA），全氟壬酸（PFNA）在110纽约州（NYS）NSP血斑复合标本收集1997年和2007年之间，共2640名婴儿。所有分析物在>= 90%的标本中检出。全氟辛烷磺酸、全氟辛烷磺酰胺、全氟硫化氢和全氟辛酸的浓度在2000年后呈指数级大幅下降，与美国逐步淘汰全氟辛烷磺酸生产的时间相吻合。我们的研究结果表明，纽约州婴儿的围产期暴露于全氟辛烷磺酸，全氟辛烷磺酸，PFHxS和全氟辛酸，并证明，第一次，实用的NSP血斑的时间趋势的评估暴露。
Temporal biomonitoring studies can assess changes in population exposures to contaminants, but collection of biological specimens with adequate representation and sufficient temporal resolution can be resource-intensive. Newborn Screening Programs (NSPs) collect blood as dried spots on filter paper from nearly all infants born in the United States (U.S.). In this study, we investigated the use of NSP blood spots for temporal biomonitoring by analyzing perfluorooctane sulfonate (PFOS), perfluorooctane sulfonamide (PFOSA), perfluorohexane sulfonate (PFHxS), perfluorooctanoic acid (PFOA), and perfluorononanoic acid (PFNA) in 110 New York State (NYS) NSP blood spot composite specimens collected between 1997 and 2007, representing a total of 2640 infants. All analytes were detected in >= 90% of the specimens. Concentrations of PFOS, PFOSA, PFHxS, and PFOA exhibited significant exponential declines after the year 2000, coinciding with the phase-out in PFOS production in the U.S. Calculated disappearance half-lives for PFOS, PFHxS, and PFOA (4.4, 8.2, and 4.1 years, respectively) were similar to biological half-lives reported for retired fluorochemical workers. Our results suggest sharp decreases in perinatal exposure of NYS infants to PFOS, PFOSA, PFHxS, and PFOA and demonstrate, for the first time, the utility of NSP blood spots for assessment of temporal trends in exposure.