DC-STAMP: A Key Regulator in Osteoclast Differentiation.
DC-STAMP: A Key Regulator in Osteoclast Differentiation.
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DOI：
10.1002/jcp.25389
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发表时间：
2016-11
影响因子：
5.6
通讯作者：
Ritchlin CT
中科院分区：
文献类型：
--
作者：
Chiu YH;Ritchlin CT
骨免疫学研究是一个新兴的研究领域，研究骨与免疫反应之间的联系。骨免疫学研究结果表明，骨不仅是肌肉骨骼系统的重要组成部分，而且还积极参与免疫调节。许多参与免疫调节的重要因素也参与骨稳态。骨稳态是由骨合成成骨细胞和骨降解破骨细胞之间的协调作用实现的。成骨细胞和破骨细胞之间的不平衡经常导致病理性骨病：骨质疏松症是由破骨细胞活动过度引起的，而骨质疏松症是由成骨细胞活动增加引起的。树突状细胞特异性跨膜蛋白（DC STAMP）是一种重要的蛋白质，目前被认为是破骨细胞发生的主要调节因子。与临床相关的是，在银屑病发病过程中循环DC STAMPþ细胞的频率升高。有趣的是，最近的研究结果表明，DC STAMP还通过调节破骨细胞和成骨细胞的分化，在骨稳态中发挥重要作用。本文从DC STAMP的相互作用蛋白、其对破骨细胞发生相关基因的调控、其可能参与免疫受体酪氨酸抑制基序（ITIM）介导的信号级联以及其开发临床治疗药物的潜力等方面综述了目前对DC STAMP的研究进展。
Osteoimmunology research is a new emerging research field that investigates the links between the bone and immune responses. Results from osteoimmunology studies suggest that bone is not only an essential component of the musculoskeletal system, but is also actively involved in immune regulation. Many important factors involved in immune regulation also participate in bone homeostasis. Bone homeostasis is achieved by a coordinated action between bone synthesizing osteoblasts and bone degrading osteoclasts. An imbalanced action between osteoblasts and osteoclasts often results in pathological bone diseases: osteoporosis is caused by an excessive osteoclast activity, whereas osteopetrosis results from an increased osteoblast activity. This review focuses on dendritic cell specific transmembrane protein (DC STAMP), an important protein currently considered as a master regulator of osteoclastogenesis. Of clinical relevance, the frequency of circulating DC STAMPþ cells is elevated during the pathogenesis of psoriatic diseases. Intriguingly, recent results suggest that DC STAMP also plays an imperative role in bone homeostasis by regulating the differentiation of both osteoclasts and osteoblasts. This article summarizes our current knowledge on DC STAMP by focusing on its interacting proteins, its regulation on osteoclastogenesis related genes, its possible involvement in immunoreceptor tyrosine based inhibitory motif (ITIM) mediated signaling cascade, and its potential of developing therapeutics for clinical applications.