Alternate histories of cytokinesis: lessons from the trypanosomatids.
Alternate histories of cytokinesis: lessons from the trypanosomatids.
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DOI：
10.1091/mbc.e19-12-0696
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发表时间：
2020-11-15
影响因子：
3.3
通讯作者：
de Graffenried CL
中科院分区：
文献类型：
--
作者：
Campbell PC;de Graffenried CL
流行文化最近产生了几部“另类历史”，描述了关键历史事件产生不同结果的世界。除了娱乐，他还问道：“这会不会以不同的方式发生？”以及“后果会是什么？”在许多研究领域，包括细胞生物学，都是探索分子机制的有价值的方法。类似于交替历史，研究相关生物的进化轨迹是如何被选择来提供一系列结果的，可以告诉我们祖先细胞基因组中包含的可塑性和潜力。在真核生物中，一组模式生物被成功地用来确定一个核心的、保守的蛋白质框架，该框架在细胞分裂期间将复制的细胞器分离成两个子细胞，这一过程被称为细胞质分裂。然而，这些生物在存在的广泛进化距离上提供了相对稀少的样本，这限制了我们对祖先真核工具包的真正潜力的了解。最近关于锥虫的工作，一组真核寄生虫，例证了胞质分裂的替代历史路线，说明了真核生物多样性的范围，特别是在单细胞生物体中。
Popular culture has recently produced several “alternate histories” that describe worlds where key historical events had different outcomes. Beyond entertainment, asking “could this have happened a different way?” and “what would the consequences be?” are valuable approaches for exploring molecular mechanisms in many areas of research, including cell biology. Analogous to alternate histories, studying how the evolutionary trajectories of related organisms have been selected to provide a range of outcomes can tell us about the plasticity and potential contained within the genome of the ancestral cell. Among eukaryotes, a group of model organisms has been employed with great success to identify a core, conserved framework of proteins that segregate the duplicated cellular organelles into two daughter cells during cell division, a process known as cytokinesis. However, these organisms provide relatively sparse sampling across the broad evolutionary distances that exist, which has limited our understanding of the true potential of the ancestral eukaryotic toolkit. Recent work on the trypanosomatids, a group of eukaryotic parasites, exemplifies alternate historical routes for cytokinesis that illustrate the range of eukaryotic diversity, especially among unicellular organisms.