Simulation and evaluation of rupturable coated capsules by finite element method
Simulation and evaluation of rupturable coated capsules by finite element method
复制标题
可破裂包衣胶囊的有限元模拟与评价
DOI：
10.1016/j.ijpharm.2017.01.027
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发表时间：
2017
影响因子：
5.8
通讯作者：
Weiguang Shan
中科院分区：
文献类型：
--
作者：
Yan Yang;Jie Fang;Lian Shen;Weiguang Shan
本研究的目的是通过有限元法（FEM）模拟和评价可破裂包衣胶囊的爆破行为。采用浸渍包衣法制备薄膜和包衣胶囊，用体视显微镜测定其尺寸。通过拉伸试验测量薄膜的力学性能，并将其用作有限元模型的材料性能。膨胀压力采用约束膨胀法确定，并施加于有限元模型的内表面。测定包衣胶囊的吸水率以研究内压的形成。采用爆破试验和体外溶解试验对有限元模型进行了验证，并对涂层爆破行为进行了研究和预测。涂层爆裂行为的模拟结果与实验结果吻合较好。膨胀压力、材料性能和涂层尺寸对最大应力有影响。计算爆破压力和临界L-HPC含量，用于爆破预测和配方优化。有限元模拟是一种可行的方法来模拟和评价包衣胶囊的爆破行为。
The objective of this study was to simulate and evaluate the burst behavior of rupturable coated capsules by finite element method (FEM). Film and coated capsules were prepared by dip-coating method and their dimensions were determined by stereomicroscope. Mechanical properties of the film were measured by tensile test and used as material properties of FEM models. Swelling pressure was determined by restrained expansion method and applied to the internal surface of FEM models. Water uptake of coated capsules was determined to study the formation of internal pressure. Burst test andin vitrodissolution was used to verify the FEM models, which were used to study and predict the coating burst behavior. Simulated results of coating burst behavior were well agreed with the experiment results. Swelling pressure, material properties and dimensions of coating had influence on the maximum stress. Burst pressure and critical L-HPC content were calculated for burst prediction and formulation optimization. FEM simulation was a feasible way to simulate and evaluate the burst behavior of coated capsules.