Assessment of monocyte to high density lipoprotein cholesterol ratio and lymphocyte-to-monocyte ratio in patients with metabolic syndrome
Assessment of monocyte to high density lipoprotein cholesterol ratio and lymphocyte-to-monocyte ratio in patients with metabolic syndrome
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DOI：
10.2217/bmm-2016-0380
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发表时间：
2017-07-01
影响因子：
2.2
通讯作者：
Huseyin, Ede
中科院分区：
文献类型：
--
作者：
Vahit, Demir;Akboga, Mehmet Kadri;Huseyin, Ede
目的：我们旨在研究代谢综合征（MS）与单核细胞与高密度脂蛋白胆固醇比值（MHR）和淋巴细胞与单核细胞比值（LMR）之间的关系。方法：纳入 762 名患者（n = 371 例存在 MS，n = 391 例不存在 MS）。结果：MHR 显着升高[13.9 (10.5-18.1) vs 11.1 (8.0-14.8)； p < 0.001]，而 LMR 显着较低 [4.5 (3.6-5.7) vs 3.6 (2.9-4.8)； p < 0.001] MS 患者。 LMR [OR：0.796（95% CI）：0.711-0.892）； p < 0.001]，MHR [OR：1.052（95% CI：1.018-1.088）； p = 0.003] 和 C 反应蛋白 [OR：1.048（95% CI：1.032-1.065）； p < 0.001] 仍然作为 MS 存在的自变量。结论：本研究表明 LMR 和 MHR 可能是 MS 的新颖且有用的指标。
Aim: We aimed to investigate the relationships between metabolic syndrome (MS) and monocyte to high density lipoprotein cholesterol ratio (MHR) and lymphocyte-to-monocyte ratio (LMR). Methods: 762 patients (n = 371 MS present and n = 391 MS absent) were enrolled. Results: MHR was significantly higher [13.9 (10.5-18.1) vs 11.1 (8.0-14.8); p < 0.001], whereas LMR was significantly lower [4.5 (3.6-5.7) vs 3.6 (2.9-4.8); p < 0.001] in patients with MS. LMR [OR: 0.796 (95% CI): 0.711-0.892); p < 0.001], MHR [OR: 1.052 (95% CI: 1.018-1.088); p = 0.003] and C-reactive protein [OR: 1.048 (95% CI: 1.032-1.065); p < 0.001] remained as independent variables for the presence of MS. Conclusion: The present study shows that both LMR and MHR may be novel and useful indicators of MS.