Sticker Microfluidics: A Method for Fabrication of Customized Monolithic Microfluidics
Sticker Microfluidics: A Method for Fabrication of Customized Monolithic Microfluidics
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DOI：
10.1021/acsbiomaterials.9b00953
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发表时间：
2019-12-01
影响因子：
5.8
通讯作者：
Li, Dachao
中科院分区：
文献类型：
--
作者：
Lai, Xiaochen;Lu, Bingyu;Li, Dachao
本文提出了一种新颖的策略和一个一体化工具箱，允许集成微流体系统的无仪器定制。与以往文献中组合多个微流控芯片的模块化设计不同，该工作首次提出了“模板贴纸”方法，其中微流控元件的牺牲模板以标准化贴纸的形式批量生产并封装到工具箱中。要创建定制的整体微流控系统，最终用户只需按照制定的步骤选择和组合各种模板贴纸即可。所制造的微流体装置具有明确的微观特征，而制造过程既便宜又省时。使用该工具箱制造并测试了各种功能性微流体装置。还展示了在弯曲表面上创建微通道的能力。作为概念验证，我们使用所提出的工具箱开发了一个用于检测亚硝酸根离子的比色测试平台。贴纸工具箱作为第一个用于微流体制造的独立便携式平台，可以快速定制整体设备，从而实现具有理想性能和可定制性的微流体的部署。
This paper proposes a novel strategy and an all-in-one toolbox that allows instrument-free customization of integrated microfluidic systems. Unlike the modular design of combining multiple microfluidic chips in the previous literature, this work, for the first time, proposes a "template sticker" method, in which sacrificial templates for microfluidic components are batch-produced in the form of standardized stickers and packaged into a toolbox. To create a customized monolithic microfluidic system, the end users only need to select and combine various template stickers following formulated steps. The fabricated microfluidic devices have well-defined microscale features, while the fabrication process is inexpensive and time-saving. Various functional microfluidic devices were fabricated and tested using this toolbox. The capability to create microchannels on curved surfaces is also demonstrated. As a proof of concept, we developed with the proposed toolbox a colorimetric testing platform for the detection of nitrite ions. The sticker toolbox, as the first self-contained portable platform for microfluidic fabrication, allows prompt customization of monolithic devices, enabling deployment of microfluidics with both ideal performance and customizability.