Correlation of contouring variation with modeled outcome for conformal non-small cell lung cancer radiotherapy
Correlation of contouring variation with modeled outcome for conformal non-small cell lung cancer radiotherapy
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DOI：
10.1016/j.radonc.2014.03.019
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发表时间：
2014-09-01
影响因子：
5.7
通讯作者：
Holloway, Lois C.
中科院分区：
文献类型：
--
作者：
Jameson, Michael G.;Kumar, Shivani;Holloway, Lois C.
背景和目的：轮廓变化是现代放射治疗中众所周知的不确定性。本研究探讨了适形非小细胞肺癌 (NSCLC) 放疗的轮廓变化、肿瘤控制概率 (TCP) 和等效均匀剂量 (EUD) 之间的关系。材料和方法：回顾性招募了 7 名患者参加研究，并由 3 名观察者根据 CT 和 PET 成像生成多个 PTV 轮廓。为每个 PTV 卷制定了计划。使用体积、位置、尺寸和合格指数（CI）对体积进行几何分析。放射生物学计划分析由两个 TCP 模型和 EUD 组成。 Spearman 相关系数 (rho) 用于量化几何变异和放射生物学指标之间的关联。结果：本研究的 CI 和 TCP 变异为 0.66-0.90% 和 0.19-0.68%。横向尺寸和体积的变化与 TCP 和 EUD 显着相关，平均 rho 分别为 -0.49 和 0.43 (p < 0.01)。结论： TCP 和几何轮廓变化显示出显着相关性。这种相关性对于 PTV 体积横向尺寸的变化最为显着。这种关联可用于评估多中心临床试验中轮廓勾画方案的违规情况，并有助于设计未来轮廓勾画研究。皇冠版权所有 (C) 2014 由 Elsevier Ireland Ltd 出版。保留所有权利。
Background and purpose: Contouring variation is a well know uncertainty in modern radiotherapy. This study investigates the relationship between contouring variation, tumor control probability (TCP) and equivalent uniform dose (EUD) for conformal non-small cell lung cancer (NSCLC) radiotherapy.Material and methods: Seven patients were retrospectively recruited to the study and multiple PTV contours were generated based on CT and PET imaging by three observers. Plans were created for each PTV volume. Volumes were analyzed geometrically using volume, location, dimension and conformity index (CI). Radiobiological plan analysis consisted of two TCP models and EUD. Spearman's correlation coefficient (rho) was used to quantify the association between geometric variation and radiobiological metrics.Results: The variation in CI and TCP for the study was 0.66-0.90% and 0.19-0.68%. Changes in lateral dimension and volume were significantly correlated with TCP and EUD with an average rho of -0.49 and 0.43 (p < 0.01) respectively.Conclusions: TCP and geometric contour variation show significant correlation. This correlation was most significant for changes in lateral dimensions of PTV volumes. This association may be used in the assessment of contouring protocol violations in multicenter clinical trials and aid in the design of future contouring studies. Crown Copyright (C) 2014 Published by Elsevier Ireland Ltd. All rights reserved.