Grand-maternal smoking in pregnancy and grandchild's autistic traits and diagnosed autism.
Grand-maternal smoking in pregnancy and grandchild's autistic traits and diagnosed autism.
复制标题
DOI：
10.1038/srep46179
复制
发表时间：
2017-04-27
影响因子：
4.6
通讯作者：
Pembrey M
中科院分区：
文献类型：
--
作者：
Golding J;Ellis G;Gregory S;Birmingham K;Iles-Caven Y;Rai D;Pembrey M
虽然对自闭症谱系障碍的遗传背景进行了大量研究，但环境因素可能会导致患病率随时间的变化。啮齿动物实验表明，环境暴露可能对后代产生影响，人类研究表明，父母产前暴露可能在发育变异中发挥作用。在这里，我们使用雅芳纵向研究的父母和孩子（ALSPAC）来测试的假设，如果母亲或父亲（F1）已暴露于自己的母亲（F0）在怀孕期间吸烟，后代（F2）将在自闭症的风险增加。我们发现外祖母在怀孕期间吸烟与孙女在社交和重复行为措施中的不良分数之间存在关联，这些措施独立预测诊断的自闭症。与此相一致，我们显示了与她孙子自闭症实际诊断的关联。祖母在怀孕期间吸烟没有表现出相关性。
Although there is considerable research into the genetic background of autism spectrum disorders, environmental factors are likely to contribute to the variation in prevalence over time. Rodent experiments indicate that environmental exposures can have effects on subsequent generations, and human studies indicate that parental prenatal exposures may play a part in developmental variation. Here we use the Avon Longitudinal Study of Parents and Children (ALSPAC) to test the hypothesis that if the mother or father (F1) had been exposed to their own mother’s (F0) smoking during pregnancy, the offspring (F2) would be at increased risk of autism. We find an association between maternal grandmother smoking in pregnancy and grand daughters having adverse scores in Social Communication and Repetitive Behaviour measures that are independently predictive of diagnosed autism. In line with this, we show an association with actual diagnosis of autism in her grandchildren. Paternal grandmothers smoking in pregnancy showed no associations.