The Multinuclear Approach to NMR Spectroscopy
The Multinuclear Approach to NMR Spectroscopy
复制标题
核磁共振波谱学的多核方法
DOI：
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发表时间：
1983
期刊：
影响因子：
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通讯作者：
F. Riddell
中科院分区：
文献类型：
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作者：
J. B. Lambert;F. Riddell
在过去的十年中，核磁共振领域经历了许多引人注目的发展。傅立叶变换方法彻底改变了信号采集能力。超导磁体提高了灵敏度，并产生了相当大的改善光谱色散。在新的应用领域，生命科学特别贝内于这些发展，并且可能是使用量增长最多的领域。核磁共振成像有望提供一种非侵入性的X射线替代品。通过魔角旋转和交叉极化，固体现在可以实现高分辨率，因此NMR的能力适用于以前难以处理的材料，如聚合物，煤和其他地球化学物质。弛豫时间的容易获得带来了一个重要的第四个变量后，化学位移，耦合常数，速率常数，检查结构和动力学问题的所有领域。软件开发，特别是脉冲序列领域的软件开发，创造了许多有用的技术，包括差异去耦和差异核奥弗豪瑟效应谱、多维显示、信号增强（INEPT）、连接性耦合常数分析（INADEQUATE）以及观察特定结构类别，例如仅季碳。最后，硬件的发展使我们能够访问整个周期表，了解无机和有机金属化学家的特殊优势。在苏格兰斯特林的北约高级研究所，与会者们从多学科的角度出发，对除成像技术外的所有这些进展进行了深入的研究。"
The field of nuclear magnetic resonance has experienced a number of spectacular developments during the last decade. Fourier transform methodology revolutionized signal acquisition capabilities. Superconducting magnets enhanced sensitivity and produced considerable improvement in spectral dispersion. In areas of new applicat ions, the life sciences particularly bene fited from these developments and probably saw the largest increase in usage. NMR imaging promises to offer a noninvasive alternative to X rays. High resolution is now achievable with solids, through magic angle spinning and cross polarization, so that the powers of NMR are applicable to previously intractable materials such as polymers, coal, and other geochemicals. The ease of obtaining relaxation times brought an important fourth variable, after the chemical shift, the coupling constant, and the rate constant, to the examination of structural and kinetic problems i all fields. Software development, particularly in the area of pulse sequences, created a host of useful tech niques, including difference decoupling and difference nuclear Overhauser effect spectra, multidimensional displays, signal enhancement (INEPT), coupling constant analysis for connectivity (INADEQUATE), and observation of specific structural classes such as only quaternary carbons. Finally, hardware development gave us access to the entire Periodic Table, to the particular advan tage of the inorganic and organometallic chemist. At the NATO Advanced Study Institute at Stirling, Scotland, the participants endeavored to examine all these advances, except imaging, from a multidisciplinary point of view."