Image-Based Patient-Specific Ventricle Models with Fluid-Structure Interaction for Cardiac Function Assessment and Surgical Design Optimization.
Image-Based Patient-Specific Ventricle Models with Fluid-Structure Interaction for Cardiac Function Assessment and Surgical Design Optimization.
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DOI：
10.1016/j.ppedcard.2010.09.007
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发表时间：
2010-12-01
影响因子：
0.9
通讯作者：
Del Nido, Pedro J
中科院分区：
文献类型：
--
作者：
Tang, Dalin;Yang, Chun;Geva, Tal;Del Nido, Pedro J
医学成像技术和计算建模技术的最新进展使得构建患者特定的计算心室模型并用于测试手术假设和取代经验性的且通常具有风险的临床实验以检查患病心脏中各种重建程序的效率和适用性成为可能。本文就心室建模的最新进展及其在法洛四联症（ToF）患者手术规划和管理中的潜在应用进行简要综述。从数据采集、模型选择和构建、组织材料特性、心室层结构和组织纤维取向、压力条件、模型验证和虚拟手术程序（改变患者特定心室数据并进行计算机模拟）等方面进行了综述。报告了使用患者特定心脏磁共振（CMR）成像和右/左心室和补片（RV/LV/补片）组合模型与流体-结构相互作用（FSI）的病例研究结果。这些模型用于评价和优化人类肺动脉瓣置换/插入（PVR）手术程序和补片设计，并测试手术假设，即PVR手术中使用小补片和积极的瘢痕组织修剪可能会改善RV功能的恢复并降低补片区域的应力/应变条件。
Recent advances in medical imaging technology and computational modeling techniques are making it possible that patient-specific computational ventricle models be constructed and used to test surgical hypotheses and replace empirical and often risky clinical experimentation to examine the efficiency and suitability of various reconstructive procedures in diseased hearts. In this paper, we provide a brief review on recent development in ventricle modeling and its potential application in surgical planning and management of tetralogy of Fallot (ToF) patients. Aspects of data acquisition, model selection and construction, tissue material properties, ventricle layer structure and tissue fiber orientations, pressure condition, model validation and virtual surgery procedures (changing patient-specific ventricle data and perform computer simulation) were reviewed. Results from a case study using patient-specific cardiac magnetic resonance (CMR) imaging and right/left ventricle and patch (RV/LV/Patch) combination model with fluid-structure interactions (FSI) were reported. The models were used to evaluate and optimize human pulmonary valve replacement/insertion (PVR) surgical procedure and patch design and test a surgical hypothesis that PVR with small patch and aggressive scar tissue trimming in PVR surgery may lead to improved recovery of RV function and reduced stress/strain conditions in the patch area.