LONGITUDINAL-STUDY OF SERUM-CHOLESTEROL, APOLIPOPROTEINS AND SEX-HORMONES DURING PUBERTY
LONGITUDINAL-STUDY OF SERUM-CHOLESTEROL, APOLIPOPROTEINS AND SEX-HORMONES DURING PUBERTY
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DOI：
10.1111/j.1651-2227.1991.tb11801.x
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发表时间：
1991-12-01
期刊：
影响因子：
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通讯作者：
VOLENIKOVA, L
中科院分区：
文献类型：
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作者：
STOZICKY, F;SLABY, P;VOLENIKOVA, L
为确定性成熟期冠心病主要危险因素的年龄和性别相关性，对普尔岑地区105名男孩和133名女孩进行了为期5年的纵向研究。捷克斯洛伐克。在13岁的女孩中，血清胆固醇显著升高(P<；0.01)，而在随访期间，其他年龄组的总胆固醇和脂蛋白胆固醇、载脂蛋白A-1和载脂蛋白B水平在性别上没有显著差异。在男孩中，总胆固醇在11到13岁之间表现出持续的和统计上显著的下降(p<；0.01)，但在研究的最后两年有上升的趋势。在女孩中，血清胆固醇在11到15岁之间显著降低(p<；0.05)。在女孩的青春期，贝塔前胆固醇在统计学上有显著的下降(p<；0.05)。β-脂蛋白胆固醇的变化与总胆固醇的变化相似。11岁至15岁男孩的载脂蛋白A-I浓度显著下降(p<；0.05)。而女孩的情况没有发生实质性的变化。在5年期间，女孩的载脂蛋白B水平永久性地显著下降(p<；0.05)。在男孩中，这种蛋白质的浓度在11到14岁之间下降，在15岁时增加，达到显著高于女孩的值(p<；0.05)。由于这些变化，女孩的载脂蛋白A-1与载脂蛋白B的比率变得更高。在研究的最后一年。与女孩相比，男孩获得睾酮/雌二醇比率的最高值与总胆固醇、前β胆固醇、β胆固醇和载脂蛋白B的浓度较高有关。另一方面，在追踪期间的最后一年中，女孩也达到了雌二醇与睾酮比率的最高水平，并伴随着较高的阿尔法胆固醇和载脂蛋白A-I浓度。
In order to determine the age and sex dependency of some of the major risk factors for coronary heart disease during the period of sexual maturation a five-year longitudinal study was carried out on 105 boys and 133 girls living in Plzen. Czechoslovakia. Serum cholesterol was significantly elevated in 13-year-old girls (p < 0.01), while no statistically significant sex-related differences in total and lipoprotein cholesterol and apolipoprotein A-1 and apolipoprotein B levels were found in other age groups during the period of follow-up. In boys the total cholesterol showed a constant and statistically significant decrease (p < 0.01) between the ages 11 to 13 years, but tended to rise during the last two years of study. In girls, serum cholesterol decreased significantly between the ages 11 to 15 years (p < 0.05). A statistically significant decrease in pre-beta cholesterol was found in girls during puberty (p < 0.05). The changes in beta lipoprotein cholesterol were similar to those for total cholesterol. The apolipoprotein A-I concentration decreased significantly between 11 and 15 years in boys (p < 0.05). while it underwent no substantial change in girls. The apolipoprotein B level decreased permanently and significantly (p < 0.05) during the 5-year period in girls. In boys, the concentration of this protein decreased between 11 and 14 years and increased during the 15th year when a value significantly higher than that for girls was attained (p < 0.05). As a result of these changes, the apolipoprotein A-1 to apolipoprotein B ratio became higher in girls. In the last year of the study. attainment of the highest value of the testosterone to estradiol ratio in boys was associated with higher concentrations of total, pre-beta, and beta cholesterol and apolipoprotein B compared with girls. On the other hand, the highest level of the estradiol to testosterone ratio, which was also attained by girls during the last year of the follow-up period, was accompanied by higher concentrations of alpha cholesterol and apolipoprotein A-I.