Catechol-O-methyltransferase (COMT) genotypes and working memory: Associations with differing cognitive operations
Catechol-O-methyltransferase (COMT) genotypes and working memory: Associations with differing cognitive operations
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DOI：
10.1016/j.biopsych.2005.05.010
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发表时间：
2005-12-01
影响因子：
10.6
通讯作者：
Gilliam, TC
中科院分区：
文献类型：
--
作者：
Bruder, GE;Keilp, JG;Gilliam, TC
背景：儿茶酚-O-甲基转移酶（COMT）是精神分裂症和认知功能障碍的一个强有力的候选基因。方法：对402名健康成年人进行了空间延迟反应（SDR）、单词序列位置测验（WSPT）、N-back和字母-数字排序等4种工作记忆测验。对子样本（n = 246）进行了威斯康星州卡片分类测试（WCST）。结果：字母-数字排序法需要存储和处理信息，是唯一显示COMT基因型之间预期差异的工作记忆测试，met/met组在WCST上的表现也优于瓦尔/瓦尔组。结论：COMT基因型与测量简单储存、维持时间秩序或更新工作记忆信息的测试表现无关。字母-数字测序和WSCT中的基因型差异表明，加工的高阶成分（例如，心理操纵）与该基因的关系更为密切。
Background: Catechol-O-methyltransferase (COMT) is a strong candidate gene for schizophrenia and cognitive functions disrupted in this disorder. The report examines the relation examines the relation of COMT genotypes to performance on a batteryof working memory tests differening on the cognitive operations to be performed on the material.Methods: A large sample of 402 healthy adults were tested on four working memory tests: Spatial Delayed Response (SDR), Word Serial Position Test (WSPT), N-back, and Letter-Number Sequencing. A subsample (n = 246) was tested on the Wisconsin Card Sorting Test (WCST). A saliva swab was used to obtain DNA from all participants.Results: Letter-Number Sequencing, which requires both storage and manipulation of information, was the only working memory test that showed expected differences among COMT genotypes, with the met/met group also performed better than the val/val group on the WCST.Conclusion: COMT genotypes were not associated with performance on tests measuring simple storage, maintenance of temperol order or updating of information in working memory. Genotype differences in Letter-Number Sequencing and WSCT suggest that higher-order components of processing (e.g., mental manipulation) are more closely related to this gene.