WALL CLIMBING, ODORS FROM THE HOME NEST AND CATECHOLAMINERGIC ACTIVITY IN RAT PUPS
WALL CLIMBING, ODORS FROM THE HOME NEST AND CATECHOLAMINERGIC ACTIVITY IN RAT PUPS
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DOI：
10.1016/0031-9384(82)90273-6
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发表时间：
1982-01-01
影响因子：
2.9
通讯作者：
SPEAR, LP
中科院分区：
文献类型：
--
作者：
BARRETT, BA;CAZA, P;SPEAR, LP
本研究考察了爬墙、巢气味、昼夜节律和儿茶酚胺能活性之间的关系。在第一个实验中，儿茶酚胺能激动剂安非他明诱导10天（而不是15天）大鼠幼鼠爬墙。在第二个实验中。-肾上腺素能拮抗剂酚妥拉明，在不影响一般运动活动的情况下，减弱足部休克引起的10日龄大鼠幼鼠爬壁。氟哌啶醇是一种多巴胺能拮抗剂，在这个年龄的大鼠幼鼠中，氟哌啶醇降低了休克引起的爬壁和一般运动活动。这些结果支持了攀壁可能部分由儿茶酚胺活性介导的假设。在实验1的黑暗周期和实验2的光照和黑暗周期中，家巢气味降低了安非他明诱导的动物爬墙和激波诱导的动物爬墙。这种由药物和休克引起的爬墙引起的家巢气味的衰减表明，家巢气味可能影响儿茶酚胺能活性的水平。
The present investigation examined the relationship among wall climbing, home nest odors, circadian rhythmicity and catecholaminergic activity. In the 1st experiment, a catecholaminergic agonist, amphetamine, induced wall climbing in 10- but not 15-day old rat pups. In the 2nd experiment an .alpha.-adrenergic antagonist, phentolamine, attenuated wall climbing elicited by foot shock in 10-day old rat pups without affecting general locomotor activity. Haloperidol, a dopaminergic antagonist, decreased both shock-elicited wall climbing and general locomotor activity in rat pups at this age. These results support the hypothesis that wall climbing may be partially mediated by catecholaminergic activity. Home nest odors decreased both amphetamine-induced wall climbing for animals tested during the dark cycle in experiment 1 and shock-induced wall climbing for subjects tested both during the light and dark phases in experiment 2. This attenuation by home nest odors of both drug- and shock-elicited wall climbing suggests that home nest odors may influence the level of catecholaminergic activity.