Simulated moving bed chromatography (SMB) for application in bioseparation.
Simulated moving bed chromatography (SMB) for application in bioseparation.
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DOI：
10.1007/3-540-45345-8_6
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
Sabine Imamoglu
中科院分区：
文献类型：
--
作者：
Sabine Imamoglu
Simulated Moving Bed (SMB) technology is of rising interest in the field of bioseparation. This is particularly due to its advantages such as reduction of solvent consumption, high productivity and final purities as well as low investment costs in comparison to eluent chromatography. SMB units can operate under high productivity overloaded conditions. This leads to nonlinear competitive adsorption behavior, which has to be accounted for when designing and optimizing new SMB separations. The so called “Triangle Theory”, which is briefly reviewed in this chapter, provides explicit criteria for the choice of the operating conditions of SMB units to achieve the prescribed separation of a mixture characterized by Langmuir, modified Langmuir and bi-Langmuir isotherms.The application of the SMB-technique to the downstream processing of biotechnological products requires some specific changes to meet the special demands of bioproduct isolation. Some exemplary applications are given including separations of sugars, proteins,monoclonal antibodies, ionic molecules and optical isomers and for desalting.
