Mediation and modification of the association between hopelessness, hostility, and progression of carotid atherosclerosis.
Mediation and modification of the association between hopelessness, hostility, and progression of carotid atherosclerosis.
复制标题
调解和改变绝望、敌意和颈动脉粥样硬化进展之间的关联。
DOI：
10.1007/s10865-005-2563-y
复制
发表时间：
2005
影响因子：
3.1
通讯作者：
Kaplan,GeorgeA
中科院分区：
文献类型：
--
作者：
Pollitt,RicardoA;Daniel,Mark;Kaufman,JayS;Lynch,JohnW;Salonen,JukkaT;Kaplan,GeorgeA
绝望和敌意与颈动脉粥样硬化（PCA）的进展有关。本研究的目的是复制这种关系，并评估的作用，涉及交感神经系统（SNS）和下丘脑-垂体-肾上腺皮质（HPA）轴的过度激活的生物途径。PCA通过1027名年龄在42-60岁的男性基线时的三种超声测量的内膜中层厚度（IMT）的4年变化进行评估。通过测量收缩压（SBP）、纤维蛋白原和腰臀比（WHR）来检查心理社会因素和PCA之间关系的影响修正和介导，这些指标的水平指示沿着这些途径的活动沿着。绝望和敌意与PCA有关。纤维蛋白原在中等程度上介导了绝望和PCA之间的关联。SBP显着修改之间的关系敌意和PCA的参与者中度敌意。上述生物学途径与连接绝望、敌意和PCA的机制有关。
Hopelessness and hostility are linked to progression of carotid atherosclerosis (PCA). The purpose of this study was to replicate such relations and to evaluate the role of biological pathways involving hyperactivation of the sympathetic nervous system (SNS) and the hypothalamic–pituitary–adrenocortical (HPA) axis. PCA was evaluated by 4-year change in three ultrasound measures of intima-media thickness (IMT) in 1027 men aged 42–60 years at baseline. Effect modification and mediation of relationships between psychosocial factors and PCA were examined for the measures systolic blood pressure (SBP), fibrinogen, and waist-to-hip ratio (WHR), levels of which are indicative of activity along these pathways. Hopelessness and hostility were associated with PCA. Fibrinogen mediated to a moderate extent the association between hopelessness and PCA. SBP significantly modified the relation between hostility and PCA in participants of moderate hostility. The above biological pathways are implicated in the mechanisms connecting hopelessness, hostility, and PCA.