Pro- and anti-inflammatory effects of short chain fatty acids on immune and endothelial cells
Pro- and anti-inflammatory effects of short chain fatty acids on immune and endothelial cells
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DOI：
10.1016/j.ejphar.2018.05.003
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发表时间：
2018-07-15
影响因子：
5
通讯作者：
Henricks, Paul A. J.
中科院分区：
文献类型：
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作者：
Li, Meng;van Esch, Betty C. A. M.;Henricks, Paul A. J.
在胃肠道中，短链脂肪酸（SCFA）对上皮细胞具有保护作用。然而，它们对内皮细胞和免疫细胞产生的炎性细胞因子以及免疫细胞的募集和它们穿过内皮层的迁移的影响仍然存在争议。这两种细胞类型都与炎性疾病的发生和发展有关，如动脉粥样硬化和脓毒症。SCFA通过激活2型和3型游离脂肪酸（FFA）受体（FFA 2和FFA 3受体）、G蛋白偶联受体109 A（GPR 109 A）和抑制组蛋白脱乙酰酶（HDAC）来调节免疫和炎症反应。本文综述了SCFAs对脂多糖（LPS）或肿瘤坏死因子-α（TNF-α）的影响，（TNF α）诱导的炎症反应对内皮细胞和免疫细胞功能的影响，并概述了SCFAs对免疫细胞和内皮细胞（包括HDAC）影响的潜在机制，FFA 2和FFA 3受体和GPR 109 A调节核因子-κ B（NF-κ B）活化和促分裂原活化蛋白激酶（MAPK）信号通路。
In the gastro-intestinal tract, short chain fatty acids (SCFAs) have protective effects on epithelial cells. However, their effects on inflammatory cytokine production by endothelial and immune cells and the recruitment of immune cells and their trans-migration across the endothelial layer remain controversial. Both cell types are associated with the initiation and development of inflammatory diseases, such as atherosclerosis and sepsis. SCFAs modulate immune and inflammatory responses via activation of free fatty acid (FFA) receptors type 2 and 3 (FFA2 and FFA3 receptors), G protein-coupled receptor 109A (GPR109A) and inhibition of histone deacetylases (HDACs). This review will focus on the effects of SCFAs on lipopolysaccharide (LPS)- or tumor necrosis factor-alpha (TNF alpha)-induced inflammatory response on endothelial and immune cells function, and an overview is presented on the underlying mechanisms of the effects of SCFAs on both immune and endothelial cells, including HDACs, FFA2 and FFA3 receptors and GPR109A regulation of nuclear factor-kappa B (NF-kappa B) activation and mitogen-activated protein kinase (MAPK) signaling pathways.