Selective C-N bond oxidation:: demethylation of N-methyl group in N-arylmethyl-N-methyl-α-amino esters utilizing N-iodosuccinimide (NIS)
Selective C-N bond oxidation:: demethylation of N-methyl group in N-arylmethyl-N-methyl-α-amino esters utilizing N-iodosuccinimide (NIS)
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DOI：
10.1016/j.tetlet.2007.11.162
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发表时间：
2008-01-21
影响因子：
1.8
通讯作者：
Node, Manabu
中科院分区：
文献类型：
--
作者：
Katoh, Takahiro;Watanabe, Tsunefumi;Node, Manabu
N-甲基-N-芳甲基-α-氨基酯中N-甲基的脱甲基是通过使用N-碘代琥珀酰亚胺（NIS）/乙腈体系氧化氨基，然后用O-甲基羟胺盐酸盐处理来完成的。这种试剂的组合可以为有机合成中的催化氢解提供补充方法，催化氢解肯定会裂解N-芳基甲基。(c)2007爱思唯尔有限公司保留所有权利。
Demethylation of N-methyl group in N-methyl-N-arylmethyl-alpha-amino esters was accomplished by the oxidation of the amino group using the N-iodosuccinimide (NIS)/acetonitrile system followed by treatment with O-methylhydroxylamine hydrochloride. This combination of reagents could provide a complementary method to catalytic hydrogenolysis, which certainly cleaves N-arylmethyl groups, in organic synthesis. (c) 2007 Elsevier Ltd. All rights reserved.