Systematic Review of the Literature on the Occurrence and Characteristics of Dyspnea in Oncology Patients.
Systematic Review of the Literature on the Occurrence and Characteristics of Dyspnea in Oncology Patients.
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DOI：
10.1016/j.critrevonc.2022.103870
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发表时间：
2022-11
期刊：
影响因子：
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通讯作者：
Joosun Shin;K. Kober;Melisa Wong;P. Yates;C. Miaskowski
中科院分区：
文献类型：
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作者：
Joosun Shin;K. Kober;Melisa Wong;P. Yates;C. Miaskowski
背景呼吸困难是肿瘤患者常见且令人痛苦的症状。然而，呼吸困难的特征并不明确，而且经常被临床医生低估。本系统综述总结了肿瘤患者呼吸困难的患病率、强度、痛苦和影响，并确定了研究空白。方法从 2009 年至 2022 年 5 月对所有相关数据库进行了检索。使用既定指南对现有文献进行了定性综合。结果 117 项研究符合纳入标准。晚期癌症患者呼吸困难的加权总平均患病率为 58.0%。呼吸困难的强度是最常见的评估维度，其次是影响和痛苦。抑郁和焦虑是与呼吸困难同时发生的最常见症状。 结论 在各项研究中，存在许多明显的方法学挑战。未来的研究需要使用有效且可靠的措施；评估呼吸困难的影响；并确定呼吸困难的生物标志物。
BackgroundDyspnea is a common and distressing symptom for oncology patients.However, dyspnea is not well-characterized and often underestimated by clinicians. This systematic review summarizes the prevalence, intensity, distress, and impact of dyspnea in oncology patients and identifies research gaps.MethodsA search of all of the relevant databases was done from 2009 to May 2022. A qualitative synthesis of the extant literature was performed using established guidelines.ResultsOne hundred-seventeen studies met inclusion criteria. Weighted grand mean prevalence of dyspnea in patients with advanced cancer was 58.0%. Intensity of dyspnea was most common dimension evaluated, followed by the impact and distress. Depression and anxiety were the most common symptoms that co-occurred with dyspnea.ConclusionNumerous methodologic challenges were evident across studies. Future studies need to use valid and reliable measures; evaluate the impact of dyspnea; and determine biomarkers for dyspnea.