Effects of mechanical ventilation on the extracellular matrix
Effects of mechanical ventilation on the extracellular matrix
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DOI：
10.1007/s00134-007-0964-9
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发表时间：
2008-04-01
影响因子：
38.9
通讯作者：
Rocco, Patricia R.
中科院分区：
文献类型：
--
作者：
Pelosi, Paolo;Rocco, Patricia R.
细胞外基质（ECM）在肺实质的生物力学行为中起着重要的作用。ECM由填充有不同大分子的三维纤维网组成，所述大分子包括糖胺聚糖和蛋白聚糖，其在许多肺病理生理过程中具有重要功能：（1）调节水合作用和水稳态，（2）维持结构和功能，（3）调节炎症反应，以及（4）影响组织修复和重塑。呼吸机诱导的肺损伤是机械通气过程中作用于肺结构（如上皮细胞和内皮细胞、细胞外基质和外周气道）的各种机械力之间复杂相互作用的结果。虽然优秀的评论已经综合了我们目前的知识，反复循环拉伸和高潮气量通气的作用，肺泡和内皮细胞，很少有解决的ECM机械通气的影响。本文综述了ECM的组织结构、机械传导与ECM的相互作用以及机械通气对ECM的影响。ECM的研究可能有助于提高我们对机械通气所致肺损伤的病理生理学的理解。
The extracellular matrix (ECM) plays an important role in the biomechanical behaviour of the lung parenchyma. The ECM is composed of a three-dimensional fibre mesh filled with different macromolecules, including the glycosaminoglycans and the proteoglycans, which have important functions in many lung pathophysiological processes: (1) regulating the hydration and water homeostasis, (2) maintaining the structure and function, (3) modulating the inflammatory response, and (4) influencing tissue repair and remodelling. Ventilator-induced lung injury is the result of a complex interplay among various mechanical forces acting on lung structures such as the epithelial and endothelial cells, the extracellular matrix, and the peripheral airways during mechanical ventilation. Although excellent reviews have synthesized our current knowledge of the role of repeated cyclic stretch and high tidal volume ventilation on alveolar and endothelial cells, few have addressed the effects of mechanical ventilation on the ECM. The present review focused on the organization of the ECM, mechanotransduction and ECM interactions, and the effects of mechanical ventilation on the ECM. The study of the ECM may be useful to improve our understanding of the pathophysiology of lung damage induced by mechanical ventilation.