Tarsal and Metatarsal Bone Mineral Density Measurement Using Volumetric Quantitative Computed Tomography
Tarsal and Metatarsal Bone Mineral Density Measurement Using Volumetric Quantitative Computed Tomography
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DOI：
10.1007/s10278-008-9118-z
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发表时间：
2009-10-01
影响因子：
4.4
通讯作者：
Mueller, Michael J.
中科院分区：
文献类型：
--
作者：
Commean, Paul K.;Ju, Tao;Mueller, Michael J.
本文介绍了一种新的测量糖尿病和周围神经病变患者跗骨和跖骨骨矿物质密度（BMD）的方法--容积定量计算机断层扫描（VQCT）。从8名受试者（平均年龄51 [11 SD]，7名男性，1名女性）中采集了两次单足VQCT图像。7个跗骨和5个跖骨的皮质壳被识别，并从相邻的骨骼中半自动分割。从每名受试者的两次采集扫描中分别测量每块骨的体积和BMD。全骨半自动分割测量误差被确定为体积和BMD的均方根变异系数分别为0.8%和0.9%。除了全骨分割方法外，我们还对所有受试者的第二跖骨进行了基于图谱的分区，从中获得每个分区的体积和BMD。在每例受试者的两次扫描之间，轴、近端和远端内的子区域测量BMD误差（均方根变异系数）的变化约为1%。新方法显示，受试者体内和受试者之间的足部12块骨头之间以及第二跖骨内的子区域之间的BMD存在很大差异。这些方法可以为临床研究试验提供重要的结果测量，这些临床研究试验调查了干预措施、衰老或疾病进展对个体足骨中骨丢失或骨获得的影响。
A new method for measuring bone mineral density (BMD) of the tarsal and metatarsals is described using volumetric quantitative computed tomography (VQCT) in subjects with diabetes mellitus and peripheral neuropathy. VQCT images of a single foot were acquired twice from eight subjects (mean age 51 [11 SD], seven males, one female). The cortical shells of the seven tarsal and five metatarsal bones were identified and semiautomatically segmented from adjacent bones. Volume and BMD of each bone were measured separately from the two acquired scans for each subject. Whole-bone semiautomatic segmentation measurement errors were determined as the root mean square coefficient of variation for the volume and BMD of 0.8% and 0.9%, respectively. In addition to the whole-bone segmentation methods, we performed atlas-based partitioning of subregions within the second metatarsal for all subjects, from which the volumes and BMDs were obtained for each subregion. The subregion measurement BMD errors (root mean square coefficient of variation) within the shaft, proximal end, and distal end were shown to vary by approximately 1% between the two scans of each subject. The new methods demonstrated large variations in BMDs between the 12 bones of the foot within a subject and between subjects, and between subregions within the second metatarsal. These methods can provide an important outcome measure for clinical research trials investigating the effects of interventions, aging, or disease progression on bone loss, or gain, in individual foot bones.