Hypoxia-Induced Oxidative Stress Modulation with Physical Activity.
Hypoxia-Induced Oxidative Stress Modulation with Physical Activity.
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DOI：
10.3389/fphys.2017.00084
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发表时间：
2017
影响因子：
4
通讯作者：
Pialoux V
中科院分区：
文献类型：
--
作者：
Debevec T;Millet GP;Pialoux V
氧化应激增加，定义为促氧化剂和抗氧化剂之间的失衡，导致分子损伤和氧化还原信号传导的中断，与许多病理生理过程相关，并且已知会加重慢性疾病。已知暴露于陆地海拔或环境O2可用性降低引起的长时间全身缺氧会引起氧化应激，从而改变健康人体的氧化还原平衡。氧化还原平衡调节也高度依赖于身体活动的水平。例如，高强度运动和不活动，代表了身体活动谱的两端，已知会促进氧化应激。许多迄今为止的研究表明，缺氧和运动可以施加叠加影响后，氧化还原平衡的改变。然而，最近的证据表明，适度的体力活动可以减轻长期低氧暴露期间的高原/低氧诱导的氧化应激。本文综述了长期低氧暴露期间不同活动水平对低氧相关氧化应激的调节作用，并探讨了氧化还原平衡变化的潜在机制。本文还探讨了适度活动作为减轻缺氧相关氧化应激的策略的适用性。此外，还讨论了这种中等强度的活动用于抵消与不活动相关的氧化应激的潜力，这种氧化应激经常出现在病理性，老年人和肥胖人群中。最后，对高原/低氧和运动对氧化应激的交互影响的研究方向进行了展望。
Increased oxidative stress, defined as an imbalance between prooxidants and antioxidants, resulting in molecular damage and disruption of redox signaling, is associated with numerous pathophysiological processes and known to exacerbate chronic diseases. Prolonged systemic hypoxia, induced either by exposure to terrestrial altitude or a reduction in ambient O2 availability is known to elicit oxidative stress and thereby alter redox balance in healthy humans. The redox balance modulation is also highly dependent on the level of physical activity. For example, both high-intensity exercise and inactivity, representing the two ends of the physical activity spectrum, are known to promote oxidative stress. Numerous to-date studies indicate that hypoxia and exercise can exert additive influence upon redox balance alterations. However, recent evidence suggests that moderate physical activity can attenuate altitude/hypoxia-induced oxidative stress during long-term hypoxic exposure. The purpose of this review is to summarize recent findings on hypoxia-related oxidative stress modulation by different activity levels during prolonged hypoxic exposures and examine the potential mechanisms underlying the observed redox balance changes. The paper also explores the applicability of moderate activity as a strategy for attenuating hypoxia-related oxidative stress. Moreover, the potential of such moderate intensity activities used to counteract inactivity-related oxidative stress, often encountered in pathological, elderly and obese populations is also discussed. Finally, future research directions for investigating interactive effects of altitude/hypoxia and exercise on oxidative stress are proposed.