Brain kinetics of L-[Β-11 C]DOPA in humans studied by positron emission tomography
Brain kinetics of L-[Β-11 C]DOPA in humans studied by positron emission tomography
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通过正电子发射断层扫描研究人类 L-[Β-11 C]DOPA 的脑动力学
DOI：
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Bengt Långström
中科院分区：
文献类型：
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作者：
Per Hartvig;Hans Ågren;L. Reibring;J. Tedroff;P. Bjurling;T. Kihlberg;Bengt Långström
用~（11）C标记体内多巴胺前体L-3，4-二羟基苯丙氨酸（L-DOPA）的B位，用正电子发射断层扫描（PET）研究了L-DOPA在脑内的利用。在健康男性志愿者中研究了L-[11 C] DOPA衍生放射性的脑摄取和动力学，并且使用缺乏特异性L-[11 C] DOPA利用的脑区域作为参考来定量特异性利用，即L-[11 C] DOPA在不同脑区域中的脱羧速率。在脑中测量的L-[11 C]多巴衍生放射性的总摄取在受试者之间变化2 - 3倍，其中纹状体区域的放射性最高。特定的利用L-[11 C]多巴放射性在纹状体区和前额叶皮层不同的主题之间的两倍。在大脑的其他区域没有观察到特定的利用。在脑中的放射性的摄取增加剂量依赖性的同时给药的未标记的左旋多巴高达10毫克。另一方面，在用1 mg/kg口服L-DOPA预处理后测量到脑放射性摄取的减少，表明竞争运输穿过血脑屏障。苄丝肼0.5 mg/ kg经口给药略微增加了脑的放射性摄取。这些药理学干扰均未对L-[11 C]多巴的特异性利用率产生明确影响。因此，在脑L-DOPA摄取和多巴胺合成的临床研究中，引入11 C-标记的L-DOPA作为成熟的L-6-[18 F]氟-DOPA方法的替代。
The in vivo dopamine precursor L-3,4-dihydroxyphenylalanine (L-DOPA) labelled with11 C in the Β position has been used for positron emission tomography studies of L-DOPA utilization in the brain. The brain uptake and kinetics of L-[11 C]DOPA-derived radioactivity were studied in healthy male volunteers, and the specific utilization, i.e. decarboxylation rate of L-[11 C]DOPA in different brain areas, was quantified using a brain region devoid of specific L-[11C]DOPA utilization as reference. Total uptake of L-[11 C]DOPA-derived radioactivity measured in the brain varied two- to threefold between subjects, with highest radioactivity in the striatal region. Specific utilization of L-[11C]DOPA radioactivity in the striatal region and in the prefrontal cortex varied twofold between subjects. No specific utilization was observed in other regions of the brain. The uptake of radioactivity in the brain increased dose-dependently with the simultaneous administration of unlabelled L-DOPA up to 10 mg. On the other hand, a decrease in brain radioactivity uptake was measured after pretreatment with 1 mg/kg oral L-DOPA, indicating competition for transport across the blood-brain barrier. Benserazide 0.5 mg/ kg orally increased somewhat the radioactivity uptake to the brain. None of these pharmacological perturbations demonstrated any clearcut effect on specific utilization of L-[11C]DOPA. Thus,11C-labelled L-DOPA is introduced as an alternative to the well-established L-6-[18 F]fluoro-DOPA methodology in clinical studies on brain L-DOPA uptake and dopamine synthesis.
L-二羟基苯丙氨酸的脑代谢。
影响因子：
3.1
作者：
Horne,MK;Cheng,CH;Wooten,GF
通讯作者：
Wooten,GF