Motorized actuation system to perform droplet operations on printed plastic sheets
Motorized actuation system to perform droplet operations on printed plastic sheets
复制标题
DOI：
10.1039/c6lc00176a
复制
发表时间：
2016-01-01
期刊：
影响因子：
6.1
通讯作者：
Pandey, Santosh
中科院分区：
文献类型：
--
作者：
Kong, Taejoon;Brien, Riley;Pandey, Santosh
我们开发了一个开放的微流控系统分配和操纵平面塑料片上的离散液滴。在这里，将超疏水材料喷涂在市售塑料片上，然后使用喷墨打印机打印亲水符号。图案化的塑料片被贴在一个双轴倾斜平台上，由步进电机驱动，为液滴运输提供机械搅拌。我们演示了以下液滴操作：不同大小的液滴的运输，多个液滴的并行运输，多个液滴的合并和混合，从大液滴或流体储器分配较小的液滴，以及液滴的单向运输。作为概念验证，实施比色测定以测量绵羊血清中的葡萄糖浓度。与基于硅的数字微流控设备相比，我们相信所提出的系统对各种生物实验具有吸引力，因为易于改变亲水性符号的设计布局，打印塑料片的周转时间相对更快，更大的面积可以容纳更多的测试，并且通过使用现成的产品降低了运营成本。
We developed an open microfluidic system to dispense and manipulate discrete droplets on planar plastic sheets. Here, a superhydrophobic material is spray-coated on commercially-available plastic sheets followed by the printing of hydrophilic symbols using an inkjet printer. The patterned plastic sheets are taped to a two-axis tilting platform, powered by stepper motors, that provides mechanical agitation for droplet transport. We demonstrate the following droplet operations: transport of droplets of different sizes, parallel transport of multiple droplets, merging and mixing of multiple droplets, dispensing of smaller droplets from a large droplet or a fluid reservoir, and one-directional transport of droplets. As a proof-of-concept, a colorimetric assay is implemented to measure the glucose concentration in sheep serum. Compared to silicon-based digital microfluidic devices, we believe that the presented system is appealing for various biological experiments because of the ease of altering design layouts of hydrophilic symbols, relatively faster turnaround time in printing plastic sheets, larger area to accommodate more tests, and lower operational costs by using off-the-shelf products.