Functional cooperation and separation of translocators in protein import into mitochondria, the double-membrane bounded organelles
Functional cooperation and separation of translocators in protein import into mitochondria, the double-membrane bounded organelles
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DOI：
10.1242/jcs.00667
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发表时间：
2003-08-15
影响因子：
4
通讯作者：
Esaki, M
中科院分区：
文献类型：
--
作者：
Endo, T;Yamamoto, H;Esaki, M
几乎所有的线粒体蛋白都是在胞浆中合成的，然后在转运子的帮助下进入线粒体：外膜的TOM复合体，内膜的TIM23和TIM22复合体。TOM复合体和TIM复合体相互协作，实现蛋白质向基质或内膜的高效转运，几个组分，包括Tom22、TIM23、Tim50和小TIM蛋白，介导两个转位系统的功能偶联。然而，TOM复合体可以与TIM系统及其能源(ATP和DeltaPsi)断开，使用替代机制来实现跨外膜的载体蛋白转运。
Nearly all mitochondrial proteins are synthesized in the cytosol and subsequently imported into mitochondria with the aid of translocators: the TOM complex in the outer membrane, and the TIM23 and TIM22 complexes in the inner membrane. The TOM complex and the TIM complexes cooperate to achieve efficient transport of proteins to the matrix or into the inner membrane and several components, including Tom22, Tim23, Tim50 and small Tim proteins, mediate functional coupling of the two translocator systems. The TOM complex can be disconnected from the TIM systems and their energy sources (ATP and DeltaPsi), however, using alternative mechanisms to achieve vectorial protein translocation across the outer membrane.