The Role of Autophagy in the Female Reproduction System: For Beginners to Experts in This Field.
The Role of Autophagy in the Female Reproduction System: For Beginners to Experts in This Field.
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自噬是维持体内平衡的一种基本机制，在生殖健康领域得到了广泛的研究。对细胞和实验动物的自噬活性进行准确的评估是可能的，但对固定组织，包括人体样本，很难进行评估。本文就自噬的相关研究进行综述，并对实验结果的解释和对自噬的认识提供一些提示。自噬是调节细胞稳态的一个基本过程。自噬是一种非选择性地降解细胞质成分以产生能量的细胞过程。在过去的几十年里，这一过程已被证明在能源生产中起作用，同时也在减少过量的蛋白质、受损的细胞器和膜运输中起作用。它导致许多人类疾病，如神经退行性疾病、致癌、糖尿病、发育、长寿和繁殖。在这篇综述中，我们为解释自噬实验的相关结果提供了重要的信息，并介绍了自噬在这一领域的作用。
Autophagy, a fundamental mechanism for maintaining homeostasis, has been studied in the field of reproductive health. Accurate evaluation of autophagy activity is possible in cells and experimental animals, but it is difficult for fixed tissues, including human samples. In this review, we introduce some studies related to autophagy in this field and provide a tip for interpreting experimental results and understanding autophagy. Autophagy is a fundamental process involved in regulating cellular homeostasis. Autophagy has been classically discovered as a cellular process that degrades cytoplasmic components non-selectively to produce energy. Over the past few decades, this process has been shown to work in energy production, as well as in the reduction of excessive proteins, damaged organelles, and membrane trafficking. It contributes to many human diseases, such as neurodegenerative diseases, carcinogenesis, diabetes mellitus, development, longevity, and reproduction. In this review, we provide important information for interpreting results related to autophagic experiments and present the role of autophagy in this field.
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影响因子：
13.3
作者：
Jacquin E;Leclerc-Mercier S;Judon C;Blanchard E;Fraitag S;Florey O
通讯作者：
Florey O
影响因子：
64.5
作者：
Goddard LM;Murphy TJ;Org T;Enciso JM;Hashimoto-Partyka MK;Warren CM;Domigan CK;McDonald AI;He H;Sanchez LA;Allen NC;Orsenigo F;Chao LC;Dejana E;Tontonoz P;Mikkola HK;Iruela-Arispe ML
通讯作者：
Iruela-Arispe ML
影响因子：
16.6
作者：
Bolton H;Graham SJL;Van der Aa N;Kumar P;Theunis K;Fernandez Gallardo E;Voet T;Zernicka-Goetz M
通讯作者：
Zernicka-Goetz M
DOI：
10.1073/pnas.1706546114
发表时间：
2017-10-03
影响因子：
11.1
作者：
Garrido-Gomez, Tamara;Dominguez, Francisco;Simon, Carlos
通讯作者：
Simon, Carlos
影响因子：
3.8
作者：
Cai, Hongcai;Chen, Li;Su, Ping
通讯作者：
Su, Ping