Correlation between novel 3D high-resolution manometry esophagogastric junction metrics and pH-metry in reflux disease patients
Correlation between novel 3D high-resolution manometry esophagogastric junction metrics and pH-metry in reflux disease patients
复制标题
反流病患者新型 3D 高分辨率测压食管胃连接处指标与 pH 测量之间的相关性
DOI：
10.1111/nmo.13344
复制
发表时间：
2018-09-01
影响因子：
3.5
通讯作者：
Kahrilas, P. J.
中科院分区：
文献类型：
--
作者：
Xiao, Y.;Lin, Z.;Kahrilas, P. J.
背景和目的我们最近开发了两种新的食管胃连接部(EGJ)收缩能力的3D高分辨率测压(HRM)指标，以区分EGJ压力的下食道括约肌(LES)和脚横膈(CD)元素。本研究旨在将这些指标与EGJ收缩积分(EGJ-CI)进行比较，并分析它们与食管酸暴露时间(AET)的相关性。方法应用3D-HRM导管对31例胃食道反流病(GERD)患者和20例对照组进行24小时pH测量和HRM检查。计算静息状态下连续3个呼吸周期的EGJ指标。使用ManoView软件中的DCI工具计算EGJ-CI。用MatLab程序计算3D-LESP和3D-DHA，3D-LESP和3D-DHA是量化3D-HRM压力地形图中CD分量的指标。结果GERD患者的3D-LESP、3D-DHA和EGJ-CI均显著低于对照组(P
Background and aimsWe recently developed 2 novel 3D high-resolution manometry (HRM) metrics of esophagogastric junction (EGJ) contractility to differentiate the lower esophageal sphincter (LES) and crural diaphragm (CD) elements of EGJ pressure. This study aimed to compare these metrics to the EGJ-contractile integral (EGJ-CI) and to analyze their correlation with esophageal acid exposure time (AET) on pH-metry.MethodsThirty-one gastro-oesophageal reflux disease (GERD) patients and 20 control subjects underwent 24-hour pH-metry and HRM using a 3D-HRM catheter. EGJ metrics were calculated during 3 consecutive respiratory cycles at rest. The EGJ-CI was calculated using the DCI tool in the ManoView software. 3D LES pressure (3D-LESP) and 3D-DHA, a metric quantifying the CD component of the 3D-HRM pressure topography, were calculated using a MATLAB program. Pearson correlation was used to calculate correlations with AET.Key Results3D-LESP, 3D-DHA, and EGJ-CI were all significantly lower in GERD patients than in control subjects (P