Formation of Neuronal Circuits by Interactions between Neuronal Populations Derived from Different Origins in the Drosophila Visual Center
Formation of Neuronal Circuits by Interactions between Neuronal Populations Derived from Different Origins in the Drosophila Visual Center
复制标题
DOI：
10.1016/j.celrep.2016.03.056
复制
发表时间：
2016-04-19
期刊：
影响因子：
8.8
通讯作者：
Sato, Makoto
中科院分区：
文献类型：
--
作者：
Suzuki, Takumi;Hasegawa, Eri;Sato, Makoto
各种各样的神经元，包括来自不同来源的群体，在大脑发育过程中与它们的伙伴精确排列并正确连接，以建立功能性神经回路。协调这些神经元的产生和排列的分子机制一直不清楚。在这里，我们证明了细胞间的相互作用在建立果蝇视觉中心不同来源的神经元的排列中起着重要的作用。特定类型的神经元出生在髓质原基外，切向迁移到发育中的髓质皮质。在它们的切向迁移过程中，这些神经元表达排斥性配体Slit，神经元插入的两层表达受体Robo2和Robo3。遗传分析表明，SlitRobo信号可能控制层细胞的定位或其过程，以形成迁移的路径。我们的研究结果表明，保守的轴突导向信号参与了大脑发育过程中不同起源的神经元之间的相互作用。
A wide variety of neurons, including populations derived from different origins, are precisely arranged and correctly connected with their partner to establish a functional neural circuit during brain development. The molecular mechanisms that orchestrate the production and arrangement of these neurons have been obscure. Here, we demonstrate that cell-cell interactions play an important role in establishing the arrangement of neurons of different origins in the Drosophila visual center. Specific types of neurons born outside the medulla primordium migrate tangentially into the developing medulla cortex. During their tangential migration, these neurons express the repellent ligand Slit, and the two layers that the neurons intercalate between express the receptors Robo2 and Robo3. Genetic analysis suggests that SlitRobo signaling may control the positioning of the layer cells or their processes to form a path for migration. Our results suggest that conserved axon guidance signaling is involved in the interactions between neurons of different origins during brain development.