Formal Synthesis of (±)-Galanthamine and (±)-Lycoramine Using Rh(I)-Catalyzed [(3+2)+1] Cycloaddition of 1-Ene-Vinylcyclopropane and CO
Formal Synthesis of (±)-Galanthamine and (±)-Lycoramine Using Rh(I)-Catalyzed [(3+2)+1] Cycloaddition of 1-Ene-Vinylcyclopropane and CO
复制标题
DOI：
10.1021/jo502604p
复制
发表时间：
2015-02-06
影响因子：
3.6
通讯作者：
Yu, Zhi-Xiang
中科院分区：
文献类型：
--
作者：
Feng, Yu;Yu, Zhi-Xiang
以Rh（I）催化的1-烯乙烯基环丙烷与CO的[（3 + 2）+ 1]环加成反应为关键步骤，建立了顺式氢化二苯并呋喃骨架，并将其用于（+/-）-加兰他敏和（+/-）-力可拉明的形式化合成。
An efficient strategy using Rh(I)-catalyzed [(3 + 2) + 1] cycloaddition of 1-enevinylcyclopropane and CO as a key step to build the cis-hydrodibenzofuran skeleton has been developed and applied for the formal synthesis of (+/-)-galanthamine and (+/-)-lycoramine.