Functional brain imaging of movement disorders.
Functional brain imaging of movement disorders.
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运动障碍的功能性脑成像。
DOI：
10.1080/01616412.2000.11740675
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发表时间：
2000
影响因子：
1.9
通讯作者：
Edwards,C
中科院分区：
文献类型：
--
作者：
Eidelberg,D;Edwards,C
正电子发射断层扫描 (PET) 等功能性脑成像技术有助于我们了解帕金森病 (PD) 和其他运动障碍的病理生理学。 PET 使用少量的正电子发射放射性配体来定量测量大脑和其他器官的生理和生化过程。在 PET 实验中，受试者被给予具有生物学意义的化合物。在 PET 研究过程中定量测量放射性示踪剂的空间和时间分布，提供区域放射性浓度的断层扫描表示。在这篇综述中，我们重点关注 PET 在选择合适候选者和评估苍白球切开术、丘脑切开术和深部脑刺激等外科手术干预方面的潜在应用。 [神经研究 2000； 22：305–312]
Functional brain imaging techniques such as positron emission tomography (PET) have contributed to our understanding of the pathophysiology of Parkinson’s disease (PD) and other movement disorders. PET employs small amounts of positron emitting radioligands to produce quantitative measures of physiological and biochemical processes in the brain and other organs. In a PET experiment, a subject is given a compound of biological interest. The spatial and temporal distribution of the radiotracer is measured quantitatively in the course of the PET study, providing a tomographic representation of regional radioactivity concentration. In this review, we focus on the potential application of PET in the selection of suitable candidates and the assessment of surgical interventions such as pallidotomy, thalamotomy, and deep brain stimulation. [Neurol Res 2000; 22: 305–312]