Mechanisms activated by kidney disease and the loss of muscle mass
Mechanisms activated by kidney disease and the loss of muscle mass
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DOI：
10.1053/ajkd.2001.29249
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发表时间：
2001-12-01
影响因子：
13.2
通讯作者：
Price, SR
中科院分区：
文献类型：
--
作者：
Mitch, WE;Price, SR
细胞蛋白质每天的周转量很大，相当于1.0至1.5公斤肌肉中所含的蛋白质。因此，即使蛋白质降解率小幅持续增加或蛋白质合成减少也会导致肌肉质量大量损失。泛素-蛋白酶体系统中蛋白质降解的激活是导致肾脏疾病中肌肉质量损失的机制。由于其他分解代谢条件也会刺激该系统导致肌肉质量损失，因此激活信号的识别很有意义。肾脏疾病的并发症——代谢性酸中毒，会通过需要糖皮质激素的过程激活肌肉中的这一系统。炎症细胞因子对肌肉中该系统的影响更为复杂，因为有证据表明细胞因子会抑制该系统，但糖皮质激素会阻止细胞因子减缓系统中蛋白质分解的作用。识别激活蛋白质分解和肌纤维重建机制的新信息将导致成功预防肾脏疾病和其他分解代谢疾病引起的肌肉质量损失的治疗方法。 (C) 2001 年，国家肾脏基金会 (National Kidney Foundation, Inc.)
The daily turnover of cellular proteins is large, with amounts equivalent to the protein contained in 1.0 to 1.5 kg of muscle. Consequently, even a small, persistent increase in the rate of protein degradation or decrease in protein synthesis will result in substantial loss of muscle mass. Activation of protein degradation in the ubiquitin-proteasome system is the mechanism contributing to loss of muscle mass in kidney disease. Because other catabolic conditions also stimulate this system to cause loss of muscle mass, the identification of activating signals is of interest. A complication of kidney disease, metabolic acidosis, activates this system in muscle by a process that requires glucocorticoids. The influence of inflammatory cytokines on this system in muscle is more complicated, as evidence indicates that cytokines suppress the system, but glucocorticoids block the effect of cytokines to slow protein breakdown in the system. New information identifying mechanisms that activate protein breakdown and the rebuilding of muscle fibers would lead to therapies that successfully prevent the loss of muscle mass in kidney disease and other catabolic illnesses. (C) 2001 by the National Kidney Foundation, Inc.