Adenovirus Core Proteins: Structure and Function.

Adenovirus Core Proteins: Structure and Function.
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DOI:
10.3390/v13030388
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发表时间:
2021-02-28
期刊:
Viruses
影响因子:
--
通讯作者:
Tikoo SK
Tikoo SK
中科院分区:
其他
文献类型:
--
作者:
Kulanayake S;Tikoo SK

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腺病毒已经作为研究病毒-细胞相互作用和发现不同细胞过程(如RNA剪接和DNA复制)的模型。此外,腺病毒作为疫苗接种和基因治疗的病毒载体的开发和评估已经导致了对腺病毒生物学的详细研究,包括腺病毒编码蛋白的结构和功能。虽然在腺病毒生物学中病毒衣壳蛋白的结构和功能的测定已经是许多报道的主题,但是最近几年已经看到对阐明腺病毒核心蛋白的结构和功能的兴趣增加。本文就腺病毒核心蛋白的结构和功能在腺病毒生物学中的研究进展作一综述。
Adenoviruses have served as a model for investigating viral-cell interactions and discovering different cellular processes, such as RNA splicing and DNA replication. In addition, the development and evaluation of adenoviruses as the viral vectors for vaccination and gene therapy has led to detailed investigations about adenovirus biology, including the structure and function of the adenovirus encoded proteins. While the determination of the structure and function of the viral capsid proteins in adenovirus biology has been the subject of numerous reports, the last few years have seen increased interest in elucidating the structure and function of the adenovirus core proteins. Here, we provide a review of research about the structure and function of the adenovirus core proteins in adenovirus biology.
腺病毒通过细胞质动力蛋白与病毒capsid己糖亚基的直接相互作用进行转运。
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