Catalytic Asymmetric Allylic Amination with Isatins, Sulfonamides, Imides, Amines, and N-Heterocycles.
Catalytic Asymmetric Allylic Amination with Isatins, Sulfonamides, Imides, Amines, and N-Heterocycles.
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DOI：
10.1021/acs.orglett.0c00936
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发表时间：
2020-04
期刊：
影响因子：
5.2
通讯作者：
C. Lynch;Kaluvu Balaraman;C. Wolf
中科院分区：
文献类型：
--
作者：
C. Lynch;Kaluvu Balaraman;C. Wolf
介绍了钯催化下靛红、磺胺、酰亚胺、胺和N-杂环化合物的不对称烯丙基胺化反应。一个单一的协议与一个容易获得的催化剂，在室温下完成这一反应，高产率和对映选择性往往超过90%，这是证明了31例。
A generally useful palladium-catalyzed method for the asymmetric allylic amination with a large variety of isatins, sulfonamides, imides, amines, and N-heterocycles is introduced. A single protocol with a readily available catalyst accomplishes this reaction at room temperature with high yields and enantioselectivities often exceeding 90%, which is demonstrated with 31 examples.