Inflammation-related factors predicting prognosis of gastric cancer
Inflammation-related factors predicting prognosis of gastric cancer
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DOI：
10.3748/wjg.v20.i16.4586
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发表时间：
2014-04-28
影响因子：
4.3
通讯作者：
Cao, Guang-Wen
中科院分区：
文献类型：
--
作者：
Chang, Wen-Jun;Du, Yan;Cao, Guang-Wen
胃癌主要由幽门螺杆菌（Helicobacter pylori，H.幽门螺杆菌）感染是发展中国家癌症相关死亡的主要原因之一。H.幽门螺杆菌感染和维持的固有免疫紊乱促进癌的发生和术后复发。然而，与H.肿瘤中的幽门螺杆菌与更好的预后有关，这可能是由于诱导了抗肿瘤免疫。肿瘤相关巨噬细胞、髓源性抑制细胞、中性粒细胞、Foxp 3（+）调节性T细胞的肿瘤浸润与不良预后相关。肿瘤浸润性CD 8+细胞毒性T淋巴细胞、树突状细胞和CD 45 RO T细胞通常与GC的良好预后相关，尽管这些免疫细胞的一些亚群具有相反的预后预测值。肿瘤中Foxp 3（+）/CD 4（+）和Foxp 3 +/CD 8+比值高与预后不良有关，而Th 1/Th 2比值高则预示预后良好。循环中高水平的白细胞介素（IL）-6、IL-10、IL-32和趋化因子C-C基序配体（CCL）7和CCL 21，CXC趋化因子受体4、趋化因子C-C基序受体（CCR）3、CCR 4、CCR 5、CCR 7、缺氧诱导因子-1 α、信号转导转录激活因子-3、环氧合酶-2的高表达，和孤儿核受体4A 2与不良预后相关。血清基质金属蛋白酶（MMP）-3、MMP-7和MMP-11水平升高以及肿瘤中MMP-9、MMP-12和MMP-21水平升高始终与GC的生存率低相关。进一步的重点应放在这些生物标志物的整合和验证在大型队列个性化预测胃癌术后预后。(C)2014百世登出版集团有限公司有限公司All rights reserved.
Gastric cancer (GC), which is mainly induced by Helico-bacter pylori (H. pylori) infection, is one of the leading causes of cancer-related death in the developing world. Active inflammation initiated by H. pylori infection and maintained by inherent immune disorders promotes carcinogenesis and postoperative recurrence. However, the presence with H. pylori in tumors has been linked to a better prognosis, possibly due to the induction of antitumor immunity. Tumor infiltrations of tumorassociated macrophages, myeloid-derived suppressor cells, neutrophils, Foxp3(+) regulatory T cells are correlated with poor prognosis. Tumor infiltrating CD8+ cytotoxic T lymphocytes, dendritic cells, and CD45RO T cells are generally associated with good prognosis of GC, although some subsets of these immune cells have inverse prognosis prediction values. High ratios of Foxp3(+)/CD4(+) and Foxp3+/CD8+ in tumors are as- pylori sociated with a poor prognosis; whereas high Th1/Th2 ratio in tumors predicts a good prognosis. High levels of interleukin (IL)-6, IL-10, IL-32, and chemokine C-C motif ligands (CCL)7 and CCL21 in circulation, high expression of CXC chemokine receptor 4, chemokine C-C motif receptor (CCR)3, CCR4, CCR5, CCR7, hypoxia-inducible factor-1 alpha, signal transducer activator of transcription-3, cyclooxygenase-2, and orphan nuclear receptor 4A2 in tumors are associated with an unfavorable prognosis. Increased serum levels of matrix metalloproteinases (MMP)-3, MMP-7, and MMP-11 and increased levels of MMP-9, MMP-12, and MMP-21 in tumors are consistently associated with poor survival of GC. Further emphasis should be put on the integration of these biomarkers and validation in large cohorts for personalized prediction of GC postoperative prognosis. (C) 2014 Baishideng Publishing Group Co., Limited. All rights reserved.