Age and gender-dependent alternative splicing of P/Q-type calcium channel EF-hand
Age and gender-dependent alternative splicing of P/Q-type calcium channel EF-hand
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DOI：
10.1016/j.neuroscience.2006.12.054
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发表时间：
2007-03-30
期刊：
影响因子：
3.3
通讯作者：
Soong, T. W.
中科院分区：
文献类型：
--
作者：
Chang, S. Y.;Yong, T. F.;Soong, T. W.
Ca（v）2.1 Ca 2+通道（P/Q型）通过介导钙内流参与中枢神经系统的各种关键作用，是广泛剪接的。它的一个选择性剪接外显子是37，它构成了EF手的一部分。外显子37 a（EFa形式）而非外显子37 b（EFb形式）的表达赋予通道活性依赖性的通道开放增强，称为Ca 2+依赖性易化（CDF）。在这项研究中，我们分析了EF手剪接变异体在小鼠，大鼠和人脑组织中的分布趋势。我们观察到啮齿类动物的发育开关，以及人类脑组织中的年龄和性别偏见，提示这些EF手剪接变体在神经生理学专业化中的可能作用。对啮齿动物大脑进行的平行研究表明，从人类和啮齿动物组织中提取的数据在衰老过程中可能不一定相关。(c)2007年IBRO。由爱思唯尔有限公司出版。保留所有权利。
Ca(v)2.1 Ca2+ channels (P/Q-type), which participate in various key roles in the CNS by mediating calcium influx, are extensively spliced. One of its alternatively-spliced exons is 37, which forms part of the EF hand. The expression of exon 37a (EFa form), but not exon 37b (EFb form), confers the channel an activity-dependent enhancement of channel opening known as Ca2+-dependent facilitation (CDF). In this study, we analyzed the trend of EF hand splice variant distributions in mouse, rat and human brain tissues. We observed a developmental switch in rodents, as well as an age and gender bias in human brain tissues, suggestive of a possible role of these EF hand splice variants in neurophysiological specialization. A parallel study performed on rodent brains showed that the data drawn from human and rodent tissues may not necessarily correlate in the process of aging. (c) 2007 IBRO. Published by Elsevier Ltd. All rights reserved.