INCIDENCE, RISK-FACTORS, AND OUTCOME OF SEVERE SEPSIS AND SEPTIC SHOCK IN ADULTS - A MULTICENTER PROSPECTIVE-STUDY IN INTENSIVE-CARE UNITS
INCIDENCE, RISK-FACTORS, AND OUTCOME OF SEVERE SEPSIS AND SEPTIC SHOCK IN ADULTS - A MULTICENTER PROSPECTIVE-STUDY IN INTENSIVE-CARE UNITS
复制标题
DOI：
10.1001/jama.274.12.968
复制
发表时间：
1995-09-27
影响因子：
120.7
通讯作者：
REGNIER, B
中科院分区：
文献类型：
--
作者：
BRUNBUISSON, C;DOYON, F;REGNIER, B
研究重症监护病房（ICU）患者严重脓毒症的发病率、危险因素和预后。来自法国公立医院170个成人ICU的11828名连续入院患者的2个月前瞻性调查的初始队列研究。符合严重脓毒症临床标准的患者被纳入并分类为有记录的感染，有记录的严重脓毒症，n=742），或无微生物记录的感染临床诊断（即，培养阴性的严重脓毒症，n=310）。严重败血症后的住院和28天死亡率。在100例ICU住院患者中，临床疑似脓毒症和确诊严重脓毒症的发生率分别为9.0（95%置信区间[CI]，8.5 - 9.5）和6.3（95% CI，5.8 - 6.7）。严重脓毒症患者的28天死亡率为56%（95%CI，52%至60%），而培养阴性的严重脓毒症患者的28天死亡率为60%（95%CI，55%至66%）。
Objective-To examine the incidence, risk factors, and outcome of severe sepsis in intensive care unit (ICU) patients.Design and Setting.-Inception cohort study from a 2-month prospective survey of 11828 consecutive admissions to 170 adult ICUs of public hospitals in France.Patients.-Patients meeting clinical criteria for severe sepsis were included and classified as having documented infection tie, documented severe sepsis, n=742), or a clinical diagnosis of infection without microbiological documentation (ie, culture-negative severe sepsis, n=310).Main Outcome Measures.-Hospital and 28-day mortality after severe sepsis.Results.-Clinically suspected sepsis and confirmed severe sepsis occurred in 9.0 (95% confidence interval [CI], 8.5 to 9.5) and 6.3 (95% CI, 5.8 to 6.7) of 100 ICU admissions, respectively. The 28-day mortality was 56% (95% CI, 52% to 60%) in patients with severe sepsis, and 60% (95% CI, 55% to 66%) in those with culture-negative severe sepsis, Major determinants of both early (