ADIPOSE EXPRESSION OF TUMOR-NECROSIS-FACTOR-ALPHA - DIRECT ROLE IN OBESITY-LINKED INSULIN RESISTANCE
ADIPOSE EXPRESSION OF TUMOR-NECROSIS-FACTOR-ALPHA - DIRECT ROLE IN OBESITY-LINKED INSULIN RESISTANCE
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肿瘤坏死因子-α的脂肪表达--在与肥胖相关的胰岛素抵抗中的直接作用
DOI：
10.1126/science.7678183
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发表时间：
1993-01-01
期刊：
影响因子：
56.9
通讯作者：
SPIEGELMAN, BM
中科院分区：
文献类型：
--
作者：
HOTAMISLIGIL, GS;SHARGILL, NS;SPIEGELMAN, BM
肿瘤坏死因子-α（TNF-α）已被证明对脂肪细胞和整个动物具有一定的分解代谢作用。在来自四种不同的肥胖和糖尿病啮齿动物模型的脂肪组织中观察到TNF-α信使RNA表达的诱导。TNF-α蛋白也局部和全身升高。在肥胖fa/fa大鼠中，TNF-α的中和作用导致对胰岛素的外周葡萄糖摄取显著增加。这些结果表明TNF-α在肥胖中的作用，特别是在胰岛素抵抗和糖尿病中，通常伴随着肥胖。
Tumor necrosis factor-alpha (TNF-alpha) has been shown to have certain catabolic effects on fat cells and whole animals. An induction of TNF-alpha messenger RNA expression was observed in adipose tissue from four different rodent models of obesity and diabetes. TNF-alpha protein was also elevated locally and systemically. Neutralization of TNF-alpha in obese fa/fa rats caused a significant increase in the peripheral uptake of glucose in response to insulin. These results indicate a role for TNF-alpha in obesity and particularly in the insulin resistance and diabetes that often accompany obesity.