Innovations in noninvasive methods for measuring gastrointestinal motility in mice
Innovations in noninvasive methods for measuring gastrointestinal motility in mice
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DOI：
10.33611/trs.2021-004
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发表时间：
2021
期刊：
影响因子：
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通讯作者：
Kazuhisa Kishi;N. Kaji;M. Hori
中科院分区：
文献类型：
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作者：
Kazuhisa Kishi;N. Kaji;M. Hori
小鼠胃肠运动的体内评估有助于了解胃肠道疾病和开发有效的治疗方法。小鼠无创测量方法的建立将有助于基础研究和临床实践之间的转化研究，这将有利于维持人类和动物的生活质量。非侵入性诊断技术的最新进展导致了在小鼠中可用测试的应用和性能的更新。体内成像技术已经发展成为评估小鼠胃肠道运动的无创方法，其中许多方法已应用于人类。影像技术，包括闪烁成像和超声成像，在临床实践中经常使用。使用临床常用的方法获得的基础数据可以直接转化为临床实践，比使用侵入性方法获得的数据更具吸引力。在这篇综述中，我们提供了推荐的无创研究小鼠胃、小肠和结肠运动的方法，并详细介绍了每种测试的好处。
In vivo assessment of murine gastrointestinal (GI) motility is useful for understanding GI diseases and developing effective therapies. The establishment of noninvasive measurement methods for mice will contribute to translational research bridging basic research and clinical practice, which can be a beneficial for maintaining quality of life in humans and animals. Recent advances in noninvasive diagnostic techniques have led to this update on the application and performance of available tests in mice. In vivo imaging techniques have been developed as noninvasive methods for the assessment of murine GI motility, and many of these methods have been applied to humans. Imaging techniques, including scintigraphy and ultrasonography, are frequently used in clinical practice. Basic data obtained using methods commonly used in clinical practice may be directly translated to clinical practice and are more attractive than those obtained using invasive methods. In this review, we provide recommended methods for noninvasively investigating gastric, small intestinal, and colonic motility in mice and detail the benefits of each test.