ISOLATION AND STRUCTURE OF MYCOBACTIN T A GROWTH FACTOR FROM MYCOBACTERIUM TUBERCULOSIS
ISOLATION AND STRUCTURE OF MYCOBACTIN T A GROWTH FACTOR FROM MYCOBACTERIUM TUBERCULOSIS
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DOI：
10.1042/bj0970166
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发表时间：
1965-01-01
影响因子：
4.1
通讯作者：
SNOW, GA
中科院分区：
文献类型：
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作者：
SNOW, GA
从结核分枝杆菌中分离到一种铁络合物生长因子，命名为铁基Mycobactin-T。铁霉菌蛋白-T是至少4种密切相关的成分的混合物，只是它们的脂肪酸侧链不同。Mycobactin-T在结构上与mycobactin-1P相似，但在以下方面有所不同：芳香酸残基是水杨酸而不是2-羟基-6-甲基苯甲酸；羟基酸残基是(+)-[β]-羟丁酸而不是(-)-3-羟基-2-甲基-戊酸；其组分具有脂肪酸侧链，这些侧链与mycobactin-P制剂中组份的侧链大部分不同。Mycobactin-T中的一个次要成分可能含有顺式-八氢-2-烯醇基侧链。主要侧链组分对应于链长C18-C21的酸，这些酸不是n-饱和酸或n-delta2-不饱和酸。讨论了分枝杆菌菌素-T和-P在生物合成上的差异。
A growth factor for Mycobacterium johnei isolated from M. tuberculosis as an Fe complex was named ferric mycobactin-T. Ferric mycobactin-T is a mixture of at least 4 closely related components differing only in their fatty-acid side chains. Mycobactin-T resembles mycobactin-1 P in structure but differs in the following respects: the aromatic acid residue is salicylic acid in place of 2-hydroxy-6-methylbenzoic acid; the hydroxy acid residue is (+)-[beta]-hydroxybutyric acid in place of (-)-3-hydroxy-2-methyl-pentanoic acid; its components have fatty-acid side chains that are mostly different from the side chains of the components in mycobactin-P preparations. One minor component in mycobactin-T probably has a cis-octadec-2-enoyl side chain. The major side-chain components correspond to acids of chain length C18-C21 that are not n-saturated or n-delta2-unsaturated acids. The differences in biosynthesis between mycobactins-T and -P are discussed.