Diffuse loss of sensitivity in early glaucoma.
Diffuse loss of sensitivity in early glaucoma.
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DOI：
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发表时间：
1999-12
影响因子：
4.4
通讯作者：
D. Henson;P. Artes;B. Chauhan
中科院分区：
文献类型：
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作者：
D. Henson;P. Artes;B. Chauhan
目的 确定早期青光眼患者群体中是否存在显着的弥漫性敏感性丧失。方法 在 38 对年龄匹配的受试者中，比较了 Humphrey 视场分析仪（Humphrey Instruments，San Leandro，CA）程序 30-2 中央 24 度内 10 个最敏感位置的光敏感度差异，其中每对一对患有早期原发性开角型青光眼 (POAG)，另一对具有正常眼睛。所有受试者都有自动视野检查的经验，并且具有清晰的介质、20/25 或更好的视力，以及对捕获试验的一种或更少的假阳性或假阴性反应。结果 青光眼受试者与正常受试者之间的平均年龄差异为 29 天（P = 0.44，最大 1.42 岁）。瞳孔大小的平均配对差异为 0.16 毫米（P = 0.26），青光眼患者的视力较高（P = 0.044）。发现受 POAG 影响的受试者中 10 个最高灵敏度测量值比正常配对成员的中值低 1.0 至 2.0 dB（0.0001<P<0.012，符号检验）。在 60% 的配对中，受 POAG 影响的眼睛第七个最敏感位置的灵敏度降低了 2 dB 或更低。结论 早期青光眼视野缺损经常涉及弥漫性成分，其中包括 10 个最敏感的位置。这些发现表明青光眼中纯粹局部视野丧失的情况很少见。这些观察结果无法用瞳孔大小和介质不透明度因素来解释。
PURPOSE To establish whether there is significant diffuse loss of sensitivity in a population of patients with early glaucoma. METHODS The differential light sensitivities at the 10 most sensitive locations from within the central 24 degrees of program 30-2 of the Humphrey Field Analyzer (Humphrey Instruments, San Leandro, CA) were compared in 38 pairs of age-matched subjects, one of each pair with early primary open-angle glaucoma (POAG) and the other with normal eyes. All subjects had had experience with automated perimetry and had clear media, visual acuity of 20/25 or better, and one or fewer false-positive or false-negative responses to catch trials. RESULTS The mean difference in age between the subjects with glaucoma and normal subjects was 29 days (P = 0.44, maximum 1.42 years). The mean paired difference in pupil size was 0.16 mm (P = 0.26), and visual acuity was higher in the glaucoma-affected subjects (P = 0.044). The 10 highest sensitivity measurements in the POAG-affected subjects were found to be lower by a median of between 1.0 and 2.0 dB than those in the normal pair members (0.0001<P<0.012, sign test). In 60% of the pairs the sensitivity at the seventh most sensitive location was 2 dB or more lower in the POAG-affected eyes. CONCLUSIONS Early glaucomatous visual field loss frequently involves a diffuse component that includes the 10 most sensitive locations. These findings suggest that purely localized visual field loss in glaucoma is rare. These observations could not be explained by factors of pupil size and media opacity.