Focal adhesion kinases in adhesion structures and disease.
Focal adhesion kinases in adhesion structures and disease.
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DOI：
10.1155/2012/296450
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Bruzzaniti A
中科院分区：
文献类型：
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作者：
Eleniste PP;Bruzzaniti A
细胞粘附于细胞外基质（ECM）对于细胞迁移、增殖和胚胎发育是必不可少的。细胞可以通过广泛的基质接触结构接触ECM，例如粘着斑、足体和侵入伪足。虽然它们在结构设计和基本功能上不同，但它们共享共同的重塑蛋白，如整合素、talin、桩蛋白和酪氨酸激酶FAK、Pyk2和Src。在本文中，我们比较和对比的基本组织和作用的局灶性粘连，podosomes和invadopodia在不同的细胞。此外，我们讨论了酪氨酸激酶，FAK，Pyk2和Src，这是不同的粘附结构的功能至关重要的作用。最后，我们从人类疾病的角度讨论了这些酪氨酸激酶的重要作用。
Cell adhesion to the extracellular matrix (ECM) is essential for cell migration, proliferation, and embryonic development. Cells can contact the ECM through a wide range of matrix contact structures such as focal adhesions, podosomes, and invadopodia. Although they are different in structural design and basic function, they share common remodeling proteins such as integrins, talin, paxillin, and the tyrosine kinases FAK, Pyk2, and Src. In this paper, we compare and contrast the basic organization and role of focal adhesions, podosomes, and invadopodia in different cells. In addition, we discuss the role of the tyrosine kinases, FAK, Pyk2, and Src, which are critical for the function of the different adhesion structures. Finally, we discuss the essential role of these tyrosine kinases from the perspective of human diseases.