Early inhaled nitric oxide therapy for term and near-term newborn infants with hypoxic respiratory failure: Neurodevelopmental follow-up
Early inhaled nitric oxide therapy for term and near-term newborn infants with hypoxic respiratory failure: Neurodevelopmental follow-up
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DOI：
10.1016/j.jpeds.2006.11.065
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发表时间：
2007-03-01
影响因子：
5.1
通讯作者：
Johnson, Yvette
中科院分区：
文献类型：
--
作者：
Konduri, G. Ganesh;Vohr, Betty;Johnson, Yvette
Objective: To report the neurodevelopmental outcome of infants enrolled in a randomized multicenter trial of early inhaled nitric oxide (iNO) in term and near-term neonates with hypoxic respiratory failure and pulmonary hypertension.Study design: Neonates born at >= 34 weeks gestation who required assisted ventilation find had an oxygenation index >= 15 and < 25 were randomized to,in early iNO group or a control group. A comprehensive neurodevelopmental assessment of survivors was performed at age 18 to 24 months.Results: The trial enrolled 299 infants, of which 266 (89%) survived to age 18 to 24 months (136 in the early iNO group and 130 in the control group). Follow-up evaluations were done on 234 (88%) of surviving infants. There were no differences between the 2 groups in the incidence of neurodevelopmental impairment (early iNO, 27%; control, 2.5%) and hearing impairment (early iNO, 23%; control, 24%). Mental development index scores were similar in the 2 groups; however, psychomotor developmental index scores were significantly higher in the control group (early iNO, 89 +/- 17.7; control, 93.5 +/- 18.4).Conclusions: Early iNO therapy for hypoxic respiratory failure in term and near-term infants is not associated with in increase in neurodevelopmental impairment or hearing loss at 18 to 24 months postnatal age.
