Population dynamics model and analysis for bacteria transformation and conjugation
Population dynamics model and analysis for bacteria transformation and conjugation
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DOI：
10.1088/2399-6528/abb8be
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发表时间：
2020-09-01
影响因子：
1.2
通讯作者：
Sampson, K.
中科院分区：
文献类型：
--
作者：
Dong, J. J.;Russo, J. D.;Sampson, K.
我们提出了一个两个物种的人口模型在一个良好的混合环境中的动态涉及，除了出生和死亡，由于环境因素和物种间的相互作用的变化。这种新的动力学成分是由细菌中产生抗生素耐药性的两种常见机制所激发的：质粒转化，其中质粒形式的外部遗传物质被转移到宿主细胞内;以及接合，其中一个细胞通过直接的细胞与细胞接触将遗传物质转移到另一个细胞。通过分析和数值计算的方法，我们分别确定的变换和共轭的影响。只有通过转化，两种群系统才会向一个种群灭绝或长期稳定共存的方向演化。只有共轭，我们发现有趣的振荡系统。此外，我们量化的综合效果的转换和共轭，并绘制稳定共存的制度，生态影响的结果。
We present a two-species population model in a well-mixed environment where the dynamics involves, in addition to birth and death, changes due to environmental factors and inter-species interactions. The novel dynamical components are motivated by two common mechanisms for developing antibiotic resistance in bacteria: plasmid transformation, where external genetic material in the form of a plasmid is transferred inside a host cell; and conjugation by which one cell transfers genetic material to another by direct cell-to-cell contact. Through analytical and numerical methods, we identify the effects of transformation and conjugation individually. With transformation only, the two-species system will evolve towards one species' extinction, or a stable co-existence in the longtime limit. With conjugation only, we discover interesting oscillations for the system. Further, we quantify the combined effects of transformation and conjugation, and chart the regimes of stable coexistence, a result with ecological implications.