Gene conversion and natural selection in the evolution of X-linked color vision genes in higher primates.
Gene conversion and natural selection in the evolution of X-linked color vision genes in higher primates.
复制标题
高等灵长类动物 X 连锁色觉基因进化中的基因转换和自然选择。
DOI：
10.1093/oxfordjournals.molbev.a025638
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发表时间：
1996
影响因子：
10.7
通讯作者：
Li,WH
中科院分区：
文献类型：
--
作者：
Zhou,YH;Li,WH
在高等灵长类动物的进化过程中，红色和绿色感光色素基因之间似乎经常发生基因转换，这些基因串联在 X 染色体上。为了更好地理解这一现象，通过 PCR 扩增了男性人类（亚洲印第安人）、雄性黑猩猩和雄性狒狒的红色和绿色色素基因的内含子 4 序列并进行了测序。数据显示，在所研究的三个物种中，两个基因之间的内含子 4 序列已强烈或完全同质化。显然，最近的基因转换事件发生在人类和黑猩猩的红色和绿色色素基因的内含子 4 中。狒狒两个色素基因的内含子 4 中可能在不同时间发生两个或多个转化事件。在每个物种中，两个基因之间的差异在内含子4中显着低于外显子4和5，这与内含子比外显子进化得更快的通常情况相反。维持红色和绿色色素基因的外显子 4 和 5 的独特功能的强烈自然选择很可能阻碍了这些外显子的序列同质化。
During higher primate evolution, gene conversion seems to have occurred often between the red and green photo-pigment genes, which are tandemly linked on the X chromosome. To understand this phenomenon better, intron 4 sequences of the red and green pigment genes of a male human (an Asian Indian), a male chimpanzee, and a male baboon were amplified by PCR and sequenced. The data show that the intron 4 sequences between the two genes have been strongly or completely homogenized in the three species studied. Apparently recent gene conversion events have occurred in introns 4 of the red and green pigment genes in humans and chimpanzees. Two or more conversion events may have occurred at different times in introns 4 of the two pigment genes in baboons. The divergence between the two genes is significantly lower in intron 4 than in exons 4 and 5 in each species, contrary to the usual situation that introns evolve faster than exons. It is most likely that strong natural selection for maintaining the distinct functions of exons 4 and 5 of the red and green pigment genes has acted against sequence homogenization of these exons.