Epidermal growth factor in the healing of corneal wounds, epidermal wounds and partial-thickness scalds. A controlled animal study.
Epidermal growth factor in the healing of corneal wounds, epidermal wounds and partial-thickness scalds. A controlled animal study.
复制标题
表皮生长因子用于角膜伤口、表皮伤口和部分烫伤的愈合。
DOI：
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发表时间：
1986
期刊：
影响因子：
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通讯作者：
G. Arturson
中科院分区：
文献类型：
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作者：
G. Arturson
观察了表皮生长因子(EGF)局部应用和腹腔给药对大鼠皮肤创面、大鼠深Ⅱ度烫伤和兔角膜创面愈合的影响。测量的指标包括每日体重变化百分比、创面完全愈合时间、创面蒸发失水量以及表皮和角膜创面上皮细胞层的新形成率。创伤动物用0.9%氯化钠溶液处理作为对照。去除角膜上皮后，局部应用EGF可明显刺激再生过程。然而，在表皮创面和部分深度烫伤中，没有观察到使用EGF治疗的显著愈合优势。这一结果不需要任何临床评估。
The effects of the topical application and the intraperitoneal administration of epidermal growth factor (EGF) on the healing of epidermal wounds, and of partial-thickness scalds in rats and of corneal wounds in rabbits were evaluated. The parameters measured were the daily percentage body weight change, time to complete healing of the wounds, the evaporative water loss from the wound surface and the rate of new formation of epithelial cell layers on the epidermal and corneal wounds. Wounded animals treated with 0.9% NaCl were used as controls. After removal of the corneal epithelium the local application of EGF stimulated the regeneration process appreciably. No significant healing advantage from the treatment with EGF was observed, however, in epidermal wounds and partial-thickness scalds. The result does not warrant any clinical evaluation.