Effect of calf death loss on cloned cattle herd derived from somatic cell nuclear transfer: clones with congenital defects would be removed by the death loss.
Effect of calf death loss on cloned cattle herd derived from somatic cell nuclear transfer: clones with congenital defects would be removed by the death loss.
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DOI：
10.1111/asj.12087
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发表时间：
2013-09
期刊：
影响因子：
--
通讯作者：
S. Watanabe
中科院分区：
文献类型：
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作者：
S. Watanabe
为了提高公众对体细胞核移植（SCNT）克隆牛的认识，本文综述了小牛死亡损失对SCNT牛群的影响。存活超过200天的SCNT牛的死亡损失率达到与常规育种牛相同的水平。这一过程可被认为是去除由小牛死亡损失引起的具有先天性缺陷的SCNT牛。通过对SCNT牛和常规饲养牛的比较研究，证实了它们在动物健康状况、产奶和产肉性能方面的实质等同性。存活至成年期的SCNT牛的两性均具有生育能力，其生殖性能（包括子代生产效率）与常规育种牛相同。它们的后代和常规繁殖的牛之间也存在实质等同性。尽管有这些科学发现，但由于缺乏公众对这些产品的接受度以及动物SCNT的低效率，政府不允许商业使用SCNT牛及其后代的食品。为了克服这种情况，需要对SCNT技术的低风险进行宣传，并进行研究以提高SCNT效率。
To increase public understanding on cloned cattle derived from somatic cell nuclear transfer (SCNT), the present review describes the effect of calf death loss on an SCNT cattle herd. The incidence of death loss in SCNT cattle surviving more than 200 days reached the same level as that in conventionally bred cattle. This process could be considered as removal of SCNT cattle with congenital defects caused by calf death loss. As a result of comparative studies of SCNT cattle and conventionally bred cattle, the substantial equivalences in animal health status, milk and meat productive performance have been confirmed. Both sexes of SCNT cattle surviving to adulthood were fertile and their reproductive performance, including efficiency of progeny production, was the same as that in conventionally bred cattle. The presence of substantial equivalence between their progeny and conventionally bred cattle also existed. Despite these scientific findings, the commercial use of food products derived from SCNT cattle and their progeny has not been allowed by governments for reasons including the lack of public acceptance of these products and the low efficiency of animal SCNT. To overcome this situation, communication of the low risk of SCNT technology and research to improve SCNT efficiency are required.