A PROSPECTIVE LONGITUDINAL-STUDY OF THE RELEASE OF OXYTOCIN AND PROLACTIN IN RESPONSE TO INFANT SUCKLING IN LONG-TERM LACTATION
A PROSPECTIVE LONGITUDINAL-STUDY OF THE RELEASE OF OXYTOCIN AND PROLACTIN IN RESPONSE TO INFANT SUCKLING IN LONG-TERM LACTATION
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DOI：
10.1210/jcem-62-4-653
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发表时间：
1986-04-01
影响因子：
5.8
通讯作者：
AMICO, JA
中科院分区：
文献类型：
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作者：
JOHNSTON, JM;AMICO, JA
我们前瞻性地研究了8名健康的产后哺乳妇女，她们在哺乳早期、中期和晚期哺乳6个月。于哺乳前每隔3分钟采血测定催产素(OT)、催乳素(PRL)和精氨酸加压素(ARP)，每15分钟连续两次哺乳。基础血浆OT在母乳喂养中没有差别[0.7.+-]。0.1(.+-.扫描电子显微镜)微U/毫升]和非哺乳妇女(0.8.+-)。0.2µU/ml)。OT显著增加(P<；0.00001)，达到5.9.+-。0.5µU/ml，并在整个喂养过程中保持较高水平。在婴儿哺乳期间，OT在一些(但不是全部)妇女中呈间歇性模式释放；不同妇女的OT峰值不同(5.0-23.3u.U/ml)。在同一天的第一次和第二次喂养中，平均刺激OT和释放模式没有显著差异。婴儿哺乳15分钟时平均释放的OT(n=8)与早期(3.9±-)无显著差异。0.3µU/ml)，中间(4.5.+-.0.3u.U/ml)和晚期(5.8.+-.0.4微U/毫升)哺乳。在四名纯母乳喂养的妇女中，在哺乳后期(8.6±-)，平均刺激的OT显著更高(P<；0.01)。0.4u.U/ml)与早期(4.6.+-)。0.4u.U/ml)或中等(6.1.+-.0.4微U/毫升)哺乳。在其他四名提供配方奶粉补充剂的女性中，OT没有改变。血浆精氨酸加压素对婴儿哺乳的反应不会增加。血浆催乳素水平随哺乳时间的延长而升高，在15min时达到高峰。平均基础催乳素水平在产后1~24周呈递减趋势。平均峰值PRL较早期显著下降(162.+-)。29)到中间(130。+-)。15)至晚(77。+-。10)ng/ml泌乳量(P<；0.05)。哺乳妇女在产后前6个月持续释放OT，以回应婴儿的哺乳，并且这种模式是可重复的。催产素的最大释放量取决于持续规律的乳头刺激。与基础和哺乳诱导的催乳素水平不同，基础和哺乳诱导的催乳素水平在产后随着时间的延长而下降，基础和哺乳诱导的催产素释放从哺乳早期到哺乳后期并没有减少。
We studied prospectively eight healthy postpartum breast-feeding women for 6 months during early, middle, and late lactation. Blood for measurement of oxytocin (OT), PRL, and arginine vasopressin was drawn before and every 3 min from each women during 15 min of infant suckling for two consecutive feedings during each stage of lactation. Basal plasma OT was not different in breast-feeding [0.7 .+-. 0.1 (.+-. SEM) .mu.U/ml] and nonbreast-feeding women (0.8 .+-. 0.2 .mu.U/ml). OT increased significantly in response to infant suckling (P < 0.00001) to 5.9 .+-. 0.5 .mu.U/ml and remained elevated throughout a feeding. OT was released during infant suckling in an episodic pattern in some, but not all, women; peak OT varied among women (5.0-23.3 .mu.U/ml). There was no significant difference in the mean stimulated OT or the pattern of release comparing the first and second feedings of the same day. The mean OT (n = 8) released during 15 min of infant suckling was not significantly different in early (3.9 .+-. 0.3 .mu.U/ml), middle (4.5 .+-. 0.3 .mu.U/ml), and late (5.8 .+-. 0.4 .mu.U/ml) lactation. In the four women who breast fed exclusively, the mean stimulated OT was significantly higher (P < 0.01) during late lactation (8.6 .+-. 0.4 .mu.U/ml) vs. early (4.6 .+-. 0.4 .mu.U/ml) or middle (6.1 .+-. 0.4 .mu.U/ml) lactation. In the other four women who provided formula supplements, OT did not change. Plasma arginine vasopressin did not increase in response to infant suckling. Plasma PRL increased in response to infant suckling, reaching a peak at 15 min. Mean basal PRL decreased progressively from weeks 1-24 postpartum. Mean peak PRL decreased significantly from early (162 .+-. 29) to middle (130 .+-. 15) to late (77 .+-. 10) ng/ml lactation (P < 0.05). OT release in response to infant suckling continues throughout the first 6 months postpartum in breast-feeding women, and the pattern is reproducible. The maximum release of OT is dependent upon continuous regular nipple stimulation. In contrast to basal and suckling-induced levels of PRL, which decreased with time postpartum, basal and suckling-induced OT release did not decrease from early to late lactation.