Adipose tissue fatty acids and risk of myocardial infarction - a case-control study
Adipose tissue fatty acids and risk of myocardial infarction - a case-control study
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DOI：
10.1038/sj.ejcn.1601064
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发表时间：
2000-08-01
影响因子：
4.7
通讯作者：
Thelle, DS
中科院分区：
文献类型：
--
作者：
Pedersen, JI;Ringstad, J;Thelle, DS
目的：研究脂肪组织中超长链n-3脂肪酸、反式脂肪酸、亚油酸和α-亚麻酸的含量与首次心肌梗死发病风险的关系。设计与对象：采用病例对照设计，100例患者和98名女性对照，年龄45~75岁，用气-液色谱法测定脂肪组织中的脂肪酸。结果：研究对象的膳食摄入量与脂肪组织中的脂肪酸含量显著相关。脂肪组织中二十碳五烯酸(20：5n-3)、二十二碳五烯酸(22：5n-3)和二十二碳六烯酸(22：6n-3)含量显著低于对照组，反式脂肪酸、亚油酸和α-亚麻酸含量显著高于对照组。年龄和性别调整后的优势比(OR)随着超长链n-3脂肪酸五分之一的增加而显著降低，因此第五和第一五分位数的OR为0.23(95%CI 0.08-0.70)。在进一步调整腰臀比、吸烟、冠心病家族史和反式脂肪酸含量后，最高5分位数的OR值为0.17(95%CI0.04~0.76)，趋势P值为0.016。年龄和性别调整后的第5位OR值分别为反式脂肪酸(OR2.81，95%CI1.16~6.84)、亚油酸(OR2.10，95%CI0.87~5.07)和α-亚麻酸(OR1.96，95%CI0.83~4.61)，趋势P值为0.002。分别为0.005和0.020。在对腰臀比、吸烟和冠心病家族史进行调整后，这一趋势仍然显著。脂肪组织中的反式脂肪酸、亚油酸和α-亚麻酸之间存在很强的相关性，这表明它们来自共同的来源，很可能是人造黄油。当这些脂肪酸中的每一种根据其他两种脂肪酸进行调整后，趋势不再显着。结论：脂肪组织内容物中反映的超长链n-3脂肪酸的摄入量与心肌梗死的风险呈负相关。反式脂肪酸、亚油酸和α-亚麻酸是相互关联的，并与增加风险相关。研究表明，风险增加可能与反式脂肪酸或其他与人造黄油消费相关的因素有关。
Objectives: To study the association between content in adipose tissue of very long-chain n-3 fatty acids, tr-ans fatty acids, linoleic acid and alpha-linolenic acid and risk of a first myocardial infarction.Design and subjects: A case-control design among 100 patients and 98 population controls both men and postmenopausal women, age 45-75 y. Adipose tissue fatty acids were determined by gas-liquid chromatography. Intake data were obtained through interview using a validated food frequency questionnaire.Results: Dietary intake and adipose tissue content of the fatty acids studied correlated significantly. Adipose tissue contents of eicosapentaenoic acid (20:5n-3), docosapentaenoic acid (22:5n-3) and docosahexaenoic acid (22:6n-3) were significantly lower while those of trans fatty acids, linoleic and alpha-linolenic acid were significantly higher in patients than in controls. Age and sex adjusted odds ratios (OR) were significantly reduced with increasing quintiles of very long-chain n-3 fatty acids, thus the OR in the fifth compared to the first quintile was 0.23 (95% CI 0.08-0.70). After further adjustment for waist-to-hip ratio, smoking, family history of CHD and content of trans fatty acids, the OR in the highest quintile was 0.17 (95% CI 0.04-0.76) and the P for trend 0.016. Age and sex adjusted OR was increased in the fifth compared to the first quintile of trans fatty acids (OR 2.81, 95% CI 1.16-6.84), linoleic acid (OR 2.10, 95% CI 0.87-5.07) and alpha-linolenic acid (OR 1.96, 95% CI 0.83-4.61), and P for trend was 0.002. 0.005 and 0.020, respectively. The trends remained significant after adjustment for waist-to-hip ratio, smoking, and family history of coronary heart disease. Trans fatty acids, linoleic acid and alpha-linolenic acid in adipose tissue were strongly correlated, indicating a common source, most likely margarine. When each of these fatty acid species were adjusted for the two others the trends were no longer significant.Conclusion: Intake of very long-chain n-3 Fatty acids as reflected in adipose tissue content is inversely associated with risk of myocardial infarction. Trans fatty acids, linoleic and alpha-linolenic acid were intercorrelated and associated with increased risk. It is suggested that the increased risk may be connected to trans fatty acids or to some other factor associated with margarine consumption.