New insights into 2-methoxyestradiol, a promising antiangiogenic and antitumor agent.
New insights into 2-methoxyestradiol, a promising antiangiogenic and antitumor agent.
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DOI：
10.1097/00001622-200311000-00004
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发表时间：
2003-11-01
影响因子：
3.4
通讯作者：
Mooberry, Susan L.
中科院分区：
文献类型：
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作者：
Mooberry, Susan L.
总之，临床前研究继续为2ME 2作为广谱药物提供热情。新的数据有助于解决2ME 2的不同细胞效应的作用，包括微管破坏，信号转导途径的启动，以及活性氧的产生，最终诱导细胞凋亡。具有上级性质的2ME 2类似物已被鉴定，并可能为第二代药物提供机会。
In summary, preclinical studies continue to provide enthusiasm for 2ME2 as a broad-spectrum agent. New data help resolve the roles of the diverse cellular effects of 2ME2 including microtubule disruption, initiation of signal transduction pathways, and generation of reactive oxygen species, which culminate in induction of apoptosis. 2ME2 analogues with superior properties have been identified and may provide opportunities for second-generation drugs.