Transcapillary Exchange En the Working Left Ventricle of the Dog
Transcapillary Exchange En the Working Left Ventricle of the Dog
复制标题
狗工作左心室的经毛细血管交换
DOI：
10.1161/01.res.29.2.181
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发表时间：
1971
影响因子：
20.1
通讯作者：
C. Goresky
中科院分区：
文献类型：
--
作者：
W. Ziegler;C. Goresky
从闭胸犬的工作心脏获得多组指示剂稀释曲线。在这些曲线上测试了渗透率受限的毛细管模型的多毛细管适应性，该模型假设交换材料在其逃逸位点返回毛细管。该模型只有两个集总参数：每个可达血管外体积的渗透性表面产品和每个血管外体积的流量。标记红细胞和白蛋白被用作血管指示剂。该模型提供了密切配合的曲线的扩散限制指标（蔗糖，菊粉，硫酸盐，钠，氯化物和尿素），并获得了两个参数的唯一值。通过该方法获得的可达血管外体积与流量无关，而每个可达血管外体积的渗透性表面积（这些指标的相对低值）随流量增加。在第一组中，流出模式随测试分子的大小而变化。对于第二组物质（水、乙醇和安替比林），流出模式几乎相同并且与分子大小无关（即，流量受限）。建模没有提供这些曲线的适当描述，并且分析表明交换指示剂可以以随机方式在毛细管之间相互连通，即，指示剂不能在其逸出的相同位置返回到每个毛细管。
Sets of multiple indicator dilution curves were obtained from working hearts of dogs with closed chests. A multiple capillary adaptation of a permeability-limited capillary model which assumes that exchanging material returns to the capillary at its site of escape was tested on these curves. The model has only two lumped parameters: a permeability surface product per accessible extravascular volume, and flow per extravascular volume. Labeled red cells and albumin were used as vascular indicators. The model provided close fits for the curves of diffusion-limited indicators (sucrose, inulin, sulfate, sodium, chloride, and urea), and unique values were obtained for both parameters. The accessible extravascular volume obtained by this method was independent of flow whereas the permeability surface product per accessible extravascular volume (a relatively low value for these indicators) increased with flow. In this first group the outflow patterns varied with the size of the test molecule. For a second group of substances (water, ethanol and antipyrine), the outflow patterns were virtually identical and independent of molecular size (i.e., flow-limited). The modeling did not provide an appropriate description of these curves, and analysis indicated that the exchanging indicator may intercommunicate between capillaries in a random fashion, i.e., that the indicator may not return to each capillary at the same site at which it escaped.